Biology:Glycoprotein IX

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene.

Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor (VWF; MIM 193400) (known as the Glycoprotein Ib-IX-V Receptor Complex). The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with GP9 and platelet glycoprotein V (GP5; MIM 173511).[supplied by OMIM]

See also

• Cluster of differentiation

Further reading

• "Genetic abnormalities of Bernard-Soulier syndrome". Int. J. Hematol. 76 (4): 319–27. 2003. doi:10.1007/BF02982690. PMID 12463594. 
• "Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3". FEBS Lett. 274 (1–2): 189–92. 1991. doi:10.1016/0014-5793(90)81361-Q. PMID 2253772. 
• "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood 69 (5): 1524–7. 1987. doi:10.1182/blood.V69.5.1524.1524. PMID 2436691. 
• "Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex". Biochemistry 28 (21): 8317–26. 1990. doi:10.1021/bi00447a009. PMID 2557900. 
• "Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures". Proc. Natl. Acad. Sci. U.S.A. 86 (17): 6773–7. 1989. doi:10.1073/pnas.86.17.6773. PMID 2771955. Bibcode: 1989PNAS...86.6773H. 
• "Isolation and characterization of human platelet glycoprotein IX". Biochem. Biophys. Res. Commun. 156 (2): 931–9. 1988. doi:10.1016/S0006-291X(88)80933-1. PMID 3056407. 
• "Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells". J. Biol. Chem. 270 (24): 14693–9. 1995. doi:10.1074/jbc.270.24.14693. PMID 7782333. 
• "Variant Bernard-Soulier syndrome associated with a homozygous mutation in the leucine-rich domain of glycoprotein IX". Blood 84 (4): 1124–31. 1994. doi:10.1182/blood.V84.4.1124.1124. PMID 8049428. 
• "Characterization of the gene encoding human platelet glycoprotein IX". J. Biol. Chem. 268 (5): 3438–43. 1993. doi:10.1016/S0021-9258(18)53713-3. PMID 8429020. 
• "Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome". Blood 81 (9): 2339–47. 1993. doi:10.1182/blood.V81.9.2339.2339. PMID 8481514. 
• "Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V". Blood 87 (4): 1385–95. 1996. doi:10.1182/blood.V87.4.1385.bloodjournal8741385. PMID 8608228. 
• "Molecular characterization of mouse T-cell ecto-ADP-ribosyltransferase Rt6: cloning of a second functional gene and identification of the Rt6 gene products". Mol. Immunol. 33 (9): 807–17. 1996. doi:10.1016/0161-5890(96)00008-9. PMID 8811076. 
• "A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with Bernard-Soulier syndrome". Br. J. Haematol. 97 (2): 312–20. 1997. doi:10.1046/j.1365-2141.1997.582706.x. PMID 9163595. http://dare.uva.nl/personal/pure/en/publications/a-phenylalanine55-to-serine-aminoacid-substitution-in-the-human-glycoprotein-ix-leucinerich-repeat-is-associated-with-bernardsoulier-syndrome(7dcf9e68-efab-4128-9481-922c67c87284).html. 
• "Corrected DNA sequence of the platelet glycoprotein IX gene". Thromb. Haemost. 77 (5): 1034–5. 1997. doi:10.1055/s-0038-1656099. PMID 9184424. 
• "Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex". Blood 90 (4): 1508–15. 1997. doi:10.1182/blood.V90.4.1508. PMID 9269768. 
• "Novel point mutation in the leucine-rich motif of the platelet glycoprotein IX associated with Bernard-Soulier syndrome". Br. J. Haematol. 99 (4): 794–800. 1998. doi:10.1046/j.1365-2141.1997.4753275.x. PMID 9432024. 
• "A new variant of Bernard-Soulier syndrome characterized by dysfunctional glycoprotein (GP) Ib and severely reduced amounts of GPIX and GPV". Br. J. Haematol. 103 (4): 1004–13. 1999. doi:10.1046/j.1365-2141.1998.01100.x. PMID 9886312. 
• "A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states". Eur. J. Biochem. 263 (1): 104–11. 1999. doi:10.1046/j.1432-1327.1999.00467.x. PMID 10429193. 
• "Cys97-->Tyr mutation in the glycoprotein IX gene associated with Bernard-Soulier syndrome". Br. J. Haematol. 107 (3): 539–45. 2000. doi:10.1046/j.1365-2141.1999.01733.x. PMID 10583255. 
• "Identification of a new mutation in platelet glycoprotein IX (GPIX) in a patient with Bernard-Soulier syndrome". Br. J. Haematol. 112 (1): 105–8. 2001. doi:10.1046/j.1365-2141.2001.02529.x. PMID 11167791. 

External links

• GP9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: P14770 (Platelet glycoprotein IX) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.