Biology:CD72
| CD72 molecule | |
|---|---|
| Identifiers | |
| Symbol | CD72 |
| NCBI gene | 971 |
| HGNC | 1696 |
| OMIM | 107272 |
| RefSeq | NM_001782 |
| UniProt | P21854 |
| Other data | |
| Locus | Chr. 9 p |
CD72 (Cluster of Differentiation 72), also known in murine biology as Lyb-2, is a protein active in the immune system of animals. It consists of two identical halves, each of about 39-43 kD, and is a C-type lectin. Its primarily locus of expression is B-cells (from the pro-B through the mature B-cell stage), where it appears to mediate aspects of B-cell - T-cell interaction. It is a ligand for CD5.[1]
CD72 is a regulatory protein on B lymphocytes. The cytoplasmic tail of CD72 contains two potential immunoreceptor tyrosine-based inhibitory motifs, one of which has been shown to recruit the tyrosine phosphatase SHP- 1. These features suggest a negative regulatory role for CD72. CD72 is a nonredundant regulator of B-cell development and a negative regulator of B-cell responsiveness.[2]
See also
References
- ↑ Cellular and Molecular Immunology (5th ed.). Saunders. 2003. p. 512. ISBN 978-0-7216-0008-6.
- ↑ "CD72, a negative regulator of B-cell responsiveness". Immunological Reviews 176 (1): 75–85. August 2000. doi:10.1034/j.1600-065x.2000.00608.x. PMID 11043769.
External links
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