Biology:FCGR3B

Generic protein structure example

FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (Cluster of Differentiation 16b), is a human gene.

Clinical relevance

Mutations and copy-number variations in this gene have been associated to clinical cases of glomerulonephritis.

See also

• CD16
• Cluster of differentiation

Further reading

• "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science 248 (4956): 732–5. May 1990. doi:10.1126/science.2139735. PMID 2139735. Bibcode: 1990Sci...248..732Q. 
• "Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG". Proceedings of the National Academy of Sciences of the United States of America 86 (3): 1013–7. Feb 1989. doi:10.1073/pnas.86.3.1013. PMID 2521732. Bibcode: 1989PNAS...86.1013P. 
• "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms". Proceedings of the National Academy of Sciences of the United States of America 86 (13): 5079–83. Jul 1989. doi:10.1073/pnas.86.13.5079. PMID 2525780. Bibcode: 1989PNAS...86.5079S. 
• "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions". The Journal of Experimental Medicine 170 (2): 481–97. Aug 1989. doi:10.1084/jem.170.2.481. PMID 2526846. 
• "The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein". Nature 333 (6173): 568–70. Jun 1988. doi:10.1038/333568a0. PMID 2967436. Bibcode: 1988Natur.333..568S. 
• "The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions". The Journal of Biological Chemistry 270 (3): 1350–61. Jan 1995. doi:10.1074/jbc.270.3.1350. PMID 7836402. 
• "Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene". The Journal of Biological Chemistry 271 (48): 30755–64. Nov 1996. doi:10.1074/jbc.271.48.30755. PMID 8940055. 
• "Characterization of a new alloantigen (SH) on the human neutrophil Fc gamma receptor IIIb". Blood 89 (3): 1027–34. Feb 1997. doi:10.1182/blood.V89.3.1027. PMID 9028335. 
• "HIV-1 Tat inhibits human natural killer cell function by blocking L-type calcium channels". Journal of Immunology 161 (6): 2938–43. Sep 1998. doi:10.4049/jimmunol.161.6.2938. PMID 9743356. 
• "The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex". Nature 406 (6793): 267–73. Jul 2000. doi:10.1038/35018508. PMID 10917521. 
• "Crystal structure of the extracellular domain of a human Fc gamma RIII". Immunity 13 (3): 387–95. Sep 2000. doi:10.1016/S1074-7613(00)00038-8. PMID 11021536. 
• "Nucleotide sequence of a new Fc gamma receptor IIIB allele that codes for a neutrophil antigen". Tissue Antigens 56 (3): 272–5. Sep 2000. doi:10.1034/j.1399-0039.2000.560310.x. PMID 11034564. 
• "Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis". Journal of Immunology 166 (11): 6735–41. Jun 2001. doi:10.4049/jimmunol.166.11.6735. PMID 11359830. 
• "Expression of FcgammaRIII (CD16) on human peripheral blood eosinophils increases in allergic conditions". The Journal of Allergy and Clinical Immunology 109 (3): 463–9. Mar 2002. doi:10.1067/mai.2002.121952. PMID 11897993. 
• "Differential role of neutrophil Fcgamma receptor IIIB (CD16) in phagocytosis, bacterial killing, and responses to immune complexes". Arthritis and Rheumatism 46 (5): 1351–61. May 2002. doi:10.1002/art.10230. PMID 12115243. 
• "FcgammaRIII expression on cultured human keratinocytes and upregulation by interferon-gamma". The Journal of Investigative Dermatology 119 (5): 1074–9. Nov 2002. doi:10.1046/j.1523-1747.2002.19527.x. PMID 12445195. 
• "Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais". Tissue Antigens 61 (5): 374–83. May 2003. doi:10.1034/j.1399-0039.2003.00047.x. PMID 12753656. 
• "No association of Fc gamma RIIa, Fc gamma RIIIa and Fc gamma RIIIb polymorphisms with MS". Journal of Neuroimmunology 140 (1–2): 210–5. Jul 2003. doi:10.1016/S0165-5728(03)00207-8. PMID 12864991. 
• "FCGR3B gene frequencies and FCGR3 variants in a Chinese population from Zhejiang Province". Annals of Hematology 82 (9): 574–8. Sep 2003. doi:10.1007/s00277-003-0725-y. PMID 12898191. 
• "Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins". Journal of Immunology 171 (11): 6090–6. Dec 2003. doi:10.4049/jimmunol.171.11.6090. PMID 14634123. 

External links

• Overview of all the structural information available in the PDB for UniProt: O75015 (Low affinity immunoglobulin gamma Fc region receptor III-B) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.