Biology:FZD9
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Frizzled-9 is a protein that in humans is encoded by the FZD9 gene.[1][2][3] FZD9 has also been designated as CD349 (cluster of differentiation 349).
Function
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.[3]
See also
References
- ↑ "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23". Human Molecular Genetics 6 (3): 465–72. Mar 1997. doi:10.1093/hmg/6.3.465. PMID 9147651.
- ↑ "Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome". Genomics 57 (2): 235–48. Apr 1999. doi:10.1006/geno.1999.5773. PMID 10198163.
- ↑ 3.0 3.1 "Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8326.
Further reading
- "Viral hepatitis (Chandigarh study)". The Journal of the Association of Physicians of India 25 (5): 325–30. May 1977. PMID 914765.
- "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proceedings of the National Academy of Sciences of the United States of America 94 (13): 6770–5. Jun 1997. doi:10.1073/pnas.94.13.6770. PMID 9192640. Bibcode: 1997PNAS...94.6770F.
- "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proceedings of the National Academy of Sciences of the United States of America 95 (17): 10164–9. Aug 1998. doi:10.1073/pnas.95.17.10164. PMID 9707618. Bibcode: 1998PNAS...9510164T.
- "Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling". The Journal of Biological Chemistry 277 (40): 37479–86. Oct 2002. doi:10.1074/jbc.M205658200. PMID 12138115.
- "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics 25 (2): 81–90. Jun 2004. doi:10.1080/13816810490514270. PMID 15370539.
- "Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation". The Journal of Biological Chemistry 280 (20): 19625–34. May 2005. doi:10.1074/jbc.M409392200. PMID 15705594.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma". The Journal of Biological Chemistry 281 (37): 26943–50. Sep 2006. doi:10.1074/jbc.M604145200. PMID 16835228.
External links
- "Frizzled Receptors: FZD9". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3067.
- FZD9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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