Biology:CD1E

Short description: Mammalian protein found in Homo sapiens

Generic protein structure example

T-cell surface glycoprotein CD1e, membrane-associated is a protein that in humans is encoded by the CD1E gene.

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Several alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined.

See also

• Cluster of differentiation

Further reading

• "CD1: antigen presentation and T cell function.". Annu. Rev. Immunol. 22 (1): 817–90. 2004. doi:10.1146/annurev.immunol.22.012703.104608. PMID 15032598. 
• "Two classes of CD1 genes.". Eur. J. Immunol. 19 (2): 285–92. 1989. doi:10.1002/eji.1830190211. PMID 2467814. 
• "A physical map linking the five CD1 human thymocyte differentiation antigen genes.". EMBO J. 8 (12): 3727–32. 1990. doi:10.1002/j.1460-2075.1989.tb08548.x. PMID 2583117. 
• "Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1.". EMBO J. 7 (9): 2801–5. 1988. doi:10.1002/j.1460-2075.1988.tb03135.x. PMID 3053166. 
• "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9154–8. 1987. doi:10.1073/pnas.83.23.9154. PMID 3097645. 
• "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. 1995. PMID 7566098. http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf. 
• "Polymorphism of human CD1 genes.". Tissue Antigens 54 (2): 122–7. 2000. doi:10.1034/j.1399-0039.1999.540202.x. PMID 10488738. https://zenodo.org/record/1231458. 
• "Identification of two novel human CD1E alleles.". Tissue Antigens 56 (2): 159–61. 2001. doi:10.1034/j.1399-0039.2000.560208.x. PMID 11019917. 
• "Two novel CD1 E alleles identified in black African individuals.". Tissue Antigens 59 (5): 417–20. 2003. doi:10.1034/j.1399-0039.2002.590509.x. PMID 12144626. 
• "Common characteristics of the human and rhesus macaque CD1e molecules: conservation of biochemical and biological properties during primate evolution.". Immunogenetics 54 (12): 842–9. 2003. doi:10.1007/s00251-003-0538-0. PMID 12671734. 
• "The cellular pathway of CD1e in immature and maturing dendritic cells.". Traffic 6 (4): 286–302. 2005. doi:10.1111/j.1600-0854.2005.00272.x. PMID 15752135. 
• "Assistance of microbial glycolipid antigen processing by CD1e.". Science 310 (5752): 1321–4. 2005. doi:10.1126/science.1115301. PMID 16311334. Bibcode: 2005Sci...310.1321D. 
• "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560. 
• "Susceptibility to Guillain–Barré syndrome is associated to polymorphisms of CD1 genes.". J. Neuroimmunol. 177 (1–2): 112–8. 2006. doi:10.1016/j.jneuroim.2006.05.018. PMID 16820217. 

External links

• CD1E+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CD1A genome location and CD1A gene details page in the UCSC Genome Browser.
• Human CD1E genome location and CD1E gene details page in the UCSC Genome Browser.