Biology:GP1BA

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b (Cluster of Differentiation 42b), is a protein that in humans is encoded by the GP1BA gene.

Function

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein receptor composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V to form the glycoprotein Ib-IX-V complex. Binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard–Soulier syndromes and platelet-type von Willebrand disease.

Interactions

GP1BA has been shown to interact with YWHAZ and FLNB.

See also

• Cluster of differentiation

Further reading

• "Genetic abnormalities of Bernard-Soulier syndrome". International Journal of Hematology 76 (4): 319–327. November 2002. doi:10.1007/BF02982690. PMID 12463594. 
• "Signaling and regulation of the platelet glycoprotein Ib-IX-V complex". Current Opinion in Hematology 14 (3): 262–269. May 2007. doi:10.1097/MOH.0b013e3280dce51a. PMID 17414217. 
• "A short history of platelet glycoprotein Ib complex". Thrombosis and Haemostasis 98 (1): 63–68. July 2007. doi:10.1160/th07-05-0327. PMID 17597992. 
• "Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. Structure/function implications". The Journal of Biological Chemistry 267 (14): 10055–10061. May 1992. doi:10.1016/S0021-9258(19)50199-5. PMID 1577776. 
• "Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness". Blood 79 (11): 3086–3090. June 1992. doi:10.1182/blood.V79.11.3086.3086. PMID 1586750. 
• "Ristocetin and botrocetin involve two distinct domains of von Willebrand factor for binding to platelet membrane glycoprotein Ib". Thrombosis and Haemostasis 64 (2): 326–332. October 1990. doi:10.1055/s-0038-1647310. PMID 1702906. 
• "Mutation of leucine-57 to phenylalanine in a platelet glycoprotein Ib alpha leucine tandem repeat occurring in patients with an autosomal dominant variant of Bernard-Soulier disease". Blood 79 (2): 439–446. January 1992. doi:10.1182/blood.V79.2.439.439. PMID 1730088. 
• "Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane". The Journal of Biological Chemistry 267 (1): 364–369. January 1992. doi:10.1016/S0021-9258(18)48503-1. PMID 1730602. 
• "Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease". Proceedings of the National Academy of Sciences of the United States of America 88 (11): 4761–4765. June 1991. doi:10.1073/pnas.88.11.4761. PMID 2052556. Bibcode: 1991PNAS...88.4761M. 
• "Identification of the disulphide bonds in human platelet glycocalicin". European Journal of Biochemistry 199 (2): 389–393. July 1991. doi:10.1111/j.1432-1033.1991.tb16135.x. PMID 2070794. 
• "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood 69 (5): 1524–1527. May 1987. doi:10.1182/blood.V69.5.1524.1524. PMID 2436691. 
• "Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex". Biochemistry 28 (21): 8317–8326. October 1989. doi:10.1021/bi00447a009. PMID 2557900. 
• "The 5' flanking region and chromosomal localization of the gene encoding human platelet membrane glycoprotein Ib alpha". Gene 85 (2): 517–524. December 1989. doi:10.1016/0378-1119(89)90446-0. PMID 2628181. 
• "Structure of the human blood platelet membrane glycoprotein Ib alpha gene". Biochemical and Biophysical Research Communications 156 (1): 389–395. October 1988. doi:10.1016/S0006-291X(88)80853-2. PMID 2845978. 
• "Structure and function of platelet membrane glycoproteins Ib and V. Effects of leukocyte elastase and other proteases on platelets response to von Willebrand factor and thrombin". European Journal of Biochemistry 153 (1): 1–11. November 1985. doi:10.1111/j.1432-1033.1985.tb09259.x. PMID 2933256. 
• "Proteolysis of platelet glycoprotein Ib by plasmin is facilitated by plasmin lysine-binding regions". Blood 68 (6): 1280–1284. December 1986. doi:10.1182/blood.V68.6.1280.1280. PMID 2946332. 
• "Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein". Proceedings of the National Academy of Sciences of the United States of America 84 (16): 5615–5619. August 1987. doi:10.1073/pnas.84.16.5615. PMID 3303030. Bibcode: 1987PNAS...84.5615L. 
• "The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence". Proceedings of the National Academy of Sciences of the United States of America 85 (7): 2135–2139. April 1988. doi:10.1073/pnas.85.7.2135. PMID 3353370. Bibcode: 1988PNAS...85.2135L. 
• "Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib". Proceedings of the National Academy of Sciences of the United States of America 84 (16): 5610–5614. August 1987. doi:10.1073/pnas.84.16.5610. PMID 3497398. Bibcode: 1987PNAS...84.5610T. 
• "The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity receptor sites for thrombin. A soluble radioreceptor assay for the interaction of thrombin with platelets". The Journal of Biological Chemistry 261 (28): 13224–13229. October 1986. doi:10.1016/S0021-9258(18)69294-4. PMID 3759960. 

External links

• GP1BA+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.