Biology:FCGR2A
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.[1][2]
Interactions
FCGR2A has been shown to interact with PIK3R1[3][4] and Syk.[4][5]
See also
References
- ↑ "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science 248 (4956): 732–5. June 1990. doi:10.1126/science.2139735. PMID 2139735. Bibcode: 1990Sci...248..732Q.
- ↑ "Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2212.
- ↑ Chacko, G W; Brandt J T; Coggeshall K M; Anderson C L (May 1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. 271 (18): 10775–81. doi:10.1074/jbc.271.18.10775. ISSN 0021-9258. PMID 8631888.
- ↑ 4.0 4.1 Ibarrola, I; Vossebeld P J; Homburg C H; Thelen M; Roos D; Verhoeven A J (July 1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta 1357 (3): 348–58. doi:10.1016/S0167-4889(97)00034-7. ISSN 0006-3002. PMID 9268059.
- ↑ Kim, M K; Pan X Q; Huang Z Y; Hunter S; Hwang P H; Indik Z K; Schreiber A D (January 2001). "Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis". Clin. Immunol. 98 (1): 125–32. doi:10.1006/clim.2000.4955. ISSN 1521-6616. PMID 11141335.
Further reading
- McKenzie SE (2002). "Humanized mouse models of FcR clearance in immune platelet disorders.". Blood Rev. 16 (1): 3–5. doi:10.1054/blre.2001.0170. PMID 11913983.
- "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products.". J. Biol. Chem. 267 (22): 15692–700. 1992. doi:10.1016/S0021-9258(19)49591-4. PMID 1379234.
- Seki T (1989). "Identification of multiple isoforms of the low-affinity human IgG Fc receptor.". Immunogenetics 30 (1): 5–12. doi:10.1007/BF02421463. PMID 2526077.
- "Quantification of macrophage cell surface molecules in rheumatoid arthritis". Clin. Exp. Immunol. 77 (1): 47–51. 1989. PMID 2527651.
- "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes". J. Exp. Med. 170 (4): 1369–85. 1989. doi:10.1084/jem.170.4.1369. PMID 2529342.
- "Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid". Science 246 (4937): 1611–3. 1990. doi:10.1126/science.2531919. PMID 2531919. Bibcode: 1989Sci...246.1611L.
- "Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII)". J. Exp. Med. 166 (6): 1668–84. 1987. doi:10.1084/jem.166.6.1668. PMID 2824655.
- "Molecular cloning of a human immunoglobulin G Fc receptor". Proc. Natl. Acad. Sci. U.S.A. 85 (7): 2240–4. 1988. doi:10.1073/pnas.85.7.2240. PMID 2965389. Bibcode: 1988PNAS...85.2240H.
- "The PI-linked receptor FcRIII is released on stimulation of neutrophils". Nature 333 (6174): 667–9. 1988. doi:10.1038/333667a0. PMID 2967437. Bibcode: 1988Natur.333..667H.
- "Assignment of the gene coding for human FcRII (CD32) to bands q23q24 on chromosome 1". Immunogenetics 28 (5): 380–1. 1988. doi:10.1007/BF00364238. PMID 2971615.
- "Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning". EMBO J. 7 (4): 1053–9. 1988. doi:10.1002/j.1460-2075.1988.tb02913.x. PMID 3402431.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. 271 (18): 10775–81. 1996. doi:10.1074/jbc.271.18.10775. PMID 8631888.
- "Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans". J. Clin. Invest. 97 (5): 1348–54. 1996. doi:10.1172/JCI118552. PMID 8636449.
- "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation". Mol. Cell. Biol. 16 (9): 4735–43. 1996. doi:10.1128/MCB.16.9.4735. PMID 8756631.
- "Human type II Fcgamma receptors inhibit B cell activation by interacting with the p21(ras)-dependent pathway". J. Biol. Chem. 271 (48): 30499–504. 1997. doi:10.1074/jbc.271.48.30499. PMID 8940017.
- "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta 1357 (3): 348–58. 1997. doi:10.1016/S0167-4889(97)00034-7. PMID 9268059.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines". Blood 91 (6): 2108–17. 1998. doi:10.1182/blood.V91.6.2108. PMID 9490697.
External links
- FCGR2A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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