Biology:KLRB1

Short description: Protein-coding gene in humans

Generic protein structure example

Killer cell lectin-like receptor subfamily B, member 1, also known as KLRB1, NKR-P1A or CD161 (cluster of differentiation 161), is a human gene.

Function

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus. NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand.

Further reading

• "Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease". Thrombosis Research 112 (4): 209–16. 2004. doi:10.1016/j.thromres.2003.11.010. PMID 14987913. 
• "Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes". Journal of Immunology 153 (6): 2417–28. September 1994. doi:10.4049/jimmunol.153.6.2417. PMID 8077657. 
• "Expression of human NKRP1A by CD34+ immature thymocytes: NKRP1A-mediated regulation of proliferation and cytolytic activity". European Journal of Immunology 26 (6): 1266–72. June 1996. doi:10.1002/eji.1830260613. PMID 8647203. 
• "The human natural killer gene complex is located on chromosome 12p12-p13". Immunogenetics 46 (4): 307–11. 1997. doi:10.1007/s002510050276. PMID 9218532. 
• "Phenotypic and functional analysis of CD4+ NKRP1A+ human T lymphocytes. Direct evidence that the NKRP1A molecule is involved in transendothelial migration". European Journal of Immunology 27 (9): 2345–50. September 1997. doi:10.1002/eji.1830270932. PMID 9341779. 
• "Expression and function of NKRP1A molecule on human monocytes and dendritic cells". European Journal of Immunology 27 (11): 2965–70. November 1997. doi:10.1002/eji.1830271132. PMID 9394825. 
• "IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A-mediated down-regulation of NK cell activation". European Journal of Immunology 28 (5): 1611–6. May 1998. doi:10.1002/(SICI)1521-4141(199805)28:05<1611::AID-IMMU1611>3.0.CO;2-6. PMID 9603467. 
• "Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function". Journal of Immunology 162 (10): 5917–23. May 1999. doi:10.4049/jimmunol.162.10.5917. PMID 10229828. 
• "CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver". European Journal of Immunology 29 (8): 2406–13. August 1999. doi:10.1002/(SICI)1521-4141(199908)29:08<2406::AID-IMMU2406>3.0.CO;2-F. PMID 10458753. 
• "CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver". Clinical and Experimental Immunology 129 (1): 92–8. July 2002. doi:10.1046/j.1365-2249.2002.01886.x. PMID 12100027. 
• "Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors". Nature Immunology 4 (8): 801–7. August 2003. doi:10.1038/ni954. PMID 12858173. 
• "Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors". Proceedings of the National Academy of Sciences of the United States of America 101 (10): 3527–32. March 2004. doi:10.1073/pnas.0308304101. PMID 14990792. Bibcode: 2004PNAS..101.3527C. 
• "Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor". Journal of Immunology 175 (12): 7791–5. December 2005. doi:10.4049/jimmunol.175.12.7791. PMID 16339512. 
• "Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor". Journal of Immunology 175 (12): 7796–9. December 2005. doi:10.4049/jimmunol.175.12.7796. PMID 16339513. 
• "CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase". Journal of Immunology 176 (4): 2397–406. February 2006. doi:10.4049/jimmunol.176.4.2397. PMID 16455998. 
• "Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161)". Xenotransplantation 13 (5): 440–6. September 2006. doi:10.1111/j.1399-3089.2006.00332.x. PMID 16925668. 
• "Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells". Journal of Immunology 180 (10): 6508–17. May 2008. doi:10.4049/jimmunol.180.10.6508. PMID 18453569. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.