Biology:CD7
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.[1]
Function
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.[1]
See also
Interactions
CD7 has been shown to interact with PIK3R1.[2][3]
Clinical significance
CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis.[4] Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary syndrome (SS).[5]
References
- ↑ 1.0 1.1 "Entrez Gene: CD7 CD7 molecule". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=924.
- ↑ "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". International Immunology 8 (8): 1195–203. August 1996. doi:10.1093/intimm/8.8.1195. PMID 8918688.
- ↑ "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover". European Journal of Immunology 33 (1): 46–52. January 2003. doi:10.1002/immu.200390006. PMID 12594831.
- ↑ "Differences in blast immunophenotypes among disease types in myelodysplastic syndromes: a multicenter validation study". Leukemia Research 36 (10): 1229–36. October 2012. doi:10.1016/j.leukres.2012.05.006. PMID 22682984.
- ↑ "Circulating CD4+CD7- lymphocyte burden and rapidity of response: predictors of outcome in the treatment of Sézary syndrome and erythrodermic mycosis fungoides with extracorporeal photopheresis". Archives of Dermatology 138 (10): 1347–50. October 2002. doi:10.1001/archderm.138.10.1347. PMID 12374541.
Further reading
- "T cell signal transduction and the role of CD7 in costimulation". Immunologic Research 24 (1): 31–52. 2002. doi:10.1385/IR:24:1:31. PMID 11485208. https://zenodo.org/record/1236301.
- "Localization of the cell surface antigen CD7 by chromosomal in situ hybridization". Immunogenetics 31 (5–6): 412–3. 1990. doi:10.1007/BF02115022. PMID 1695199.
- "Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene". Proceedings of the National Academy of Sciences of the United States of America 88 (2): 603–7. January 1991. doi:10.1073/pnas.88.2.603. PMID 1703303. Bibcode: 1991PNAS...88..603S.
- "Molecular cloning of the gene coding for the human T cell differentiation antigen CD7". Immunogenetics 33 (5–6): 352–60. 1991. doi:10.1007/BF00216694. PMID 1711009.
- "Characterization of the surface topography and putative tertiary structure of the human CD7 molecule". Journal of Immunology 143 (11): 3632–40. December 1989. doi:10.4049/jimmunol.143.11.3632. PMID 2479685.
- "Assignment of a gene coding for a human T-cell antigen with a molecular weight of 40,000 daltons to chromosome 17". Cytogenetics and Cell Genetics 47 (1–2): 8–10. 1988. doi:10.1159/000132494. PMID 3258561.
- "Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system". The EMBO Journal 6 (11): 3313–6. November 1987. doi:10.1002/j.1460-2075.1987.tb02651.x. PMID 3501369.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters". Immunogenetics 44 (2): 108–14. 1996. doi:10.1007/s002510050097. PMID 8662072.
- "Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L". The Journal of Experimental Medicine 183 (4): 1331–8. April 1996. doi:10.1084/jem.183.4.1331. PMID 8666891.
- "Interaction between the extracellular domain of CD7 and concanavalin A: a clue to the identity of the ligand for CD7". Cellular Immunology 173 (1): 15–21. October 1996. doi:10.1006/cimm.1996.0247. PMID 8871597.
- "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". International Immunology 8 (8): 1195–203. August 1996. doi:10.1093/intimm/8.8.1195. PMID 8918688.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms". Genomics 47 (3): 327–40. February 1998. doi:10.1006/geno.1997.5151. PMID 9480746.
- "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry 273 (51): 34171–9. December 1998. doi:10.1074/jbc.273.51.34171. PMID 9852078.
- "Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1". Journal of Immunology 163 (7): 3801–11. October 1999. doi:10.4049/jimmunol.163.7.3801. PMID 10490978.
- "Identification of CD7 as a cognate of the human K12 (SECTM1) protein". The Journal of Biological Chemistry 275 (5): 3431–7. February 2000. doi:10.1074/jbc.275.5.3431. PMID 10652336.
- "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29". The Journal of Biological Chemistry 276 (35): 33054–60. August 2001. doi:10.1074/jbc.M009913200. PMID 11423532.
- "B lymphopoiesis is active throughout human life, but there are developmental age-related changes". Blood 101 (2): 576–84. January 2003. doi:10.1182/blood-2002-03-0896. PMID 12393702.
External links
- CD7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CD7 genome location and CD7 gene details page in the UCSC Genome Browser.
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