Biology:CEACAM1

Short description: Mammalian protein found in Homo sapiens

Generic protein structure example

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1) also known as CD66a (Cluster of Differentiation 66a), is a human glycoprotein, and a member of the carcinoembryonic antigen (CEA) gene family.

Function

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell–cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.

In melanocytic cells CEACAM1 gene expression may be regulated by MITF.

Interactions

CEACAM1 has been shown to interact with PTPN11 and Annexin A2.

See also

• Carcinoembryonic antigen
• Cluster of differentiation

Further reading

• "CEACAM1: contact-dependent control of immunity". Nature Reviews. Immunology 6 (6): 433–46. June 2006. doi:10.1038/nri1864. PMID 16724098. 
• "Immunofluorescence studies on the occurrence and localization of the CEA-related biliary glycoprotein I (BGP I) in normal human gastrointestinal tissues". Clinical and Experimental Immunology 36 (3): 436–41. June 1979. PMID 385181. 
• "Long-range chromosomal mapping of the carcinoembryonic antigen (CEA) gene family cluster". Genomics 12 (4): 761–72. April 1992. doi:10.1016/0888-7543(92)90307-E. PMID 1572649. https://epub.ub.uni-muenchen.de/7101/. 
• "Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library". Biochemical and Biophysical Research Communications 176 (2): 578–85. April 1991. doi:10.1016/S0006-291X(05)80223-2. PMID 2025273. 
• "Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen". Proceedings of the National Academy of Sciences of the United States of America 85 (18): 6959–63. September 1988. doi:10.1073/pnas.85.18.6959. PMID 2457922. Bibcode: 1988PNAS...85.6959H. 
• "Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family". The Journal of Cell Biology 108 (2): 267–76. February 1989. doi:10.1083/jcb.108.2.267. PMID 2537311. 
• "Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas". Proceedings of the National Academy of Sciences of the United States of America 90 (22): 10744–8. November 1993. doi:10.1073/pnas.90.22.10744. PMID 7504281. Bibcode: 1993PNAS...9010744N. 
• "Receptor-mediated internalization of insulin. Potential role of pp120/HA4, a substrate of the insulin receptor kinase". The Journal of Biological Chemistry 270 (41): 24073–7. October 1995. doi:10.1074/jbc.270.26.15844. PMID 7592607. 
• "Cell- and region-specific expression of biliary glycoprotein and its messenger RNA in normal human colonic mucosa". Cancer Research 55 (14): 2963–7. July 1995. PMID 7606710. 
• "Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase". Biochemistry 34 (29): 9341–9. July 1995. doi:10.1021/bi00029a009. PMID 7626603. 
• "Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene". European Journal of Biochemistry 231 (1): 104–14. July 1995. doi:10.1111/j.1432-1033.1995.tb20676.x. PMID 7628460. 
• "CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant". Blood 84 (1): 200–10. July 1994. doi:10.1182/blood.V84.1.200.200. PMID 8018919. 
• "Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas". European Journal of Biochemistry 223 (2): 529–41. July 1994. doi:10.1111/j.1432-1033.1994.tb19022.x. PMID 8055923. 
• "Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins". Molecular and Cellular Biology 13 (2): 1273–82. February 1993. doi:10.1128/mcb.13.2.1273. PMID 8423792. 
• "Immunochemical analysis of carcinoembryonic antigen (CEA)-related antigens differentially localized in intracellular granules of human neutrophils". Immunological Investigations 24 (5): 829–43. August 1995. doi:10.3109/08820139509060710. PMID 8543346. 
• "The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells". The Journal of Biological Chemistry 274 (1): 335–44. January 1999. doi:10.1074/jbc.274.1.335. PMID 9867848. 
• "Identification of CD66a and CD66b as the major galectin-3 receptor candidates in human neutrophils". Journal of Immunology 163 (10): 5592–8. November 1999. doi:10.4049/jimmunol.163.10.5592. PMID 10553088. 
• "The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor". Molecular and Cellular Biology 20 (11): 3896–905. June 2000. doi:10.1128/MCB.20.11.3896-3905.2000. PMID 10805733. 
• "CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor". Molecular Cell 5 (2): 311–20. February 2000. doi:10.1016/S1097-2765(00)80426-8. PMID 10882072. 
• "C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers". Clinical Cancer Research 6 (8): 2988–93. August 2000. PMID 10955775. 

External links

• CEACAM1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CEACAM1 genome location and CEACAM1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.