Biology:FZD10
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Frizzled-10 is a protein that in humans is encoded by the FZD10 gene.[1][2] FZD10 has also been designated as CD350 (cluster of differentiation 350).
Function
This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.[2]
See also
References
- ↑ "Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family". Biochemical and Biophysical Research Communications 262 (1): 39–43. Aug 1999. doi:10.1006/bbrc.1999.1161. PMID 10448064.
- ↑ 2.0 2.1 "Entrez Gene: FZD10 frizzled homolog 10 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11211.
Further reading
- "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proceedings of the National Academy of Sciences of the United States of America 94 (13): 6770–5. Jun 1997. doi:10.1073/pnas.94.13.6770. PMID 9192640. Bibcode: 1997PNAS...94.6770F.
- "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proceedings of the National Academy of Sciences of the United States of America 95 (17): 10164–9. Aug 1998. doi:10.1073/pnas.95.17.10164. PMID 9707618. Bibcode: 1998PNAS...9510164T.
- "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries". Osteoarthritis and Cartilage 9 (7): 641–53. Oct 2001. doi:10.1053/joca.2001.0421. PMID 11597177.
- "Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway". International Journal of Molecular Medicine 9 (2): 107–12. Feb 2002. doi:10.3892/ijmm.9.2.107. PMID 11786918.
- "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics 25 (2): 81–90. Jun 2004. doi:10.1080/13816810490514270. PMID 15370539.
External links
- "Frizzled Receptors: FZD10". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3068.
- FZD10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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