Biology:CEACAM5
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a member of the carcinoembryonic antigen (CEA) gene family.[1]
Functions
In the literature, CEACAM5 is often used as a synonym for cancer embryonic antigen (CEA), a well-known biomarker of many types of malignancies, such as colorectal cancer and non-small-cell lung cancer.[2][3] Its primary function in the embryonic intestine and colon tumors is adhesion between epithelial cells.[4] Also, it plays a significant role in the inhibition of differentiation [5] and apoptosis [6] in colon cells. There are evidences that high CEACAM5 expression is firmly associated with the CD133-positive colorectal cancer stem cells.[7] High CEACAM5 expression has also been identified in ~25% of patients with advanced non-squamous (NSq) non-small cell lung cancer (NSCLC) detectable via IHC (immunohistochemistry).[8][9]
See also
References
- ↑ "Entrez Gene: CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1048.
- ↑ "Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis". Cancer and Metastasis Reviews 32 (3–4): 643–671. December 2013. doi:10.1007/s10555-013-9444-6. PMID 23903773.
- ↑ "CEACAM5 stimulates the progression of non-small-cell lung cancer by promoting cell proliferation and migration". The Journal of International Medical Research 48 (9): 300060520959478. September 2020. doi:10.1177/0300060520959478. PMID 32993395.
- ↑ "Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule". Cell 57 (2): 327–334. April 1989. doi:10.1016/0092-8674(89)90970-7. PMID 2702691.
- ↑ "Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation". Neoplasia 4 (2): 151–163. 2002. doi:10.1038/sj.neo.7900201. PMID 11896570.
- ↑ "Human carcinoembryonic antigen functions as a general inhibitor of anoikis". Cancer Research 60 (13): 3419–3424. July 2000. PMID 10910050. https://pubmed.ncbi.nlm.nih.gov/10910050.
- ↑ "CEACAM5 overexpression is a reliable characteristic of CD133-positive colorectal cancer stem cells". Cancer Biomarkers 32 (1): 85–98. 2021-01-01. doi:10.3233/CBM-203187. PMID 34092615.
- ↑ "Validation of an immunohistochemical assay, CEACAM5 IHC 769, under development for use with the antibody-drug conjugate tusamitamab ravtansine (SAR408701)." (in en). Journal of Clinical Oncology 39 (15_suppl): e21030. 2021-05-20. doi:10.1200/JCO.2021.39.15_suppl.e21030. ISSN 0732-183X.
- ↑ "Chimeric antigen receptor-T cells are effective against CEACAM5 expressing non-small cell lung cancer cells resistant to antibody-drug conjugates". Frontiers in Oncology 13: 1124039. 2023-02-27. doi:10.3389/fonc.2023.1124039. PMID 36923424.
Further reading
- "Characterization of the genomic organization of human carcinoembryonic antigen (CEA): comparison with other family members and sequence analysis of 5' controlling region". Genomics 8 (3): 492–500. November 1990. doi:10.1016/0888-7543(90)90036-T. PMID 2286372.
- "Workshop report: proposed nomenclature for the carcinoembryonic antigen (CEA) gene family". Tumour Biology 11 (1–2): 59–63. 1990. doi:10.1159/000217643. PMID 2309067.
- "Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression". Molecular and Cellular Biology 10 (6): 2738–2748. June 1990. doi:10.1128/MCB.10.6.2738. PMID 2342461.
- "Carcinoembryonic antigen family: expression in a mouse L-cell transfectant and characterization of a partial cDNA in bacteriophage lambda gt11". Proceedings of the National Academy of Sciences of the United States of America 84 (15): 5350–5354. August 1987. doi:10.1073/pnas.84.15.5350. PMID 2955415. Bibcode: 1987PNAS...84.5350K.
- "Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure". Proceedings of the National Academy of Sciences of the United States of America 84 (9): 2960–2964. May 1987. doi:10.1073/pnas.84.9.2960. PMID 3033671. Bibcode: 1987PNAS...84.2960Z.
- "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains". Genomics 3 (1): 59–66. July 1988. doi:10.1016/0888-7543(88)90160-7. PMID 3220478.
- "Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors". Cancer Research 48 (9): 2550–2554. May 1988. PMID 3356015.
- "Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen". Molecular and Cellular Biology 7 (9): 3221–3230. September 1987. doi:10.1128/MCB.7.9.3221. PMID 3670312.
- "Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence". Biochemical and Biophysical Research Communications 142 (2): 511–518. January 1987. doi:10.1016/0006-291X(87)90304-4. PMID 3814146.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes". Cell Death and Differentiation 7 (5): 493–503. May 2000. doi:10.1038/sj.cdd.4400680. PMID 10800083.
- "Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells". Infection and Immunity 68 (6): 3554–3563. June 2000. doi:10.1128/IAI.68.6.3554-3563.2000. PMID 10816511.
- "Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23". FEBS Letters 475 (1): 11–16. June 2000. doi:10.1016/S0014-5793(00)01612-4. PMID 10854848.
- "The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor". The Journal of Cell Biology 150 (3): 613–626. August 2000. doi:10.1083/jcb.150.3.613. PMID 10931872.
- "Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells". The Journal of Biological Chemistry 276 (33): 31067–31073. August 2001. doi:10.1074/jbc.M104093200. PMID 11406629.
- "Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth". Clinical & Experimental Metastasis 19 (2): 155–160. 2002. doi:10.1023/A:1014566127493. PMID 11964079.
- "Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer". International Journal of Cancer 101 (6): 545–548. October 2002. doi:10.1002/ijc.90009. PMID 12237895.
- "Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells". Oncogene 21 (51): 7817–7823. November 2002. doi:10.1038/sj.onc.1205906. PMID 12420218.
External links
- CEACAM5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CEACAM5 genome location and CEACAM5 gene details page in the UCSC Genome Browser.
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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