Biology:IL18RAP
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene.[1][2]
Function
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18.[1]
Disease association
Variants at IL18RAP have been linked to susceptibility to Coeliac disease.[3]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: IL18RAP interleukin 18 receptor accessory protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8807.
- ↑ "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling". J. Biol. Chem. 273 (45): 29445–50. November 1998. doi:10.1074/jbc.273.45.29445. PMID 9792649.
- ↑ "Novel celiac disease genetic determinants related to the immune response". Nat. Genet. 40 (4): 395–402. April 2008. doi:10.1038/ng.102. PMID 18311140.
Further reading
- "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling". J. Biol. Chem. 273 (45): 29445–50. 1998. doi:10.1074/jbc.273.45.29445. PMID 9792649.
- "IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells". J. Immunol. 165 (4): 1933–8. 2000. doi:10.4049/jimmunol.165.4.1933. PMID 10925275.
- "Human keratinocytes constitutively produce but do not process interleukin-18". Br. J. Dermatol. 143 (2): 330–6. 2000. doi:10.1046/j.1365-2133.2000.03759.x. PMID 10951141.
- "IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18". J. Immunol. 165 (9): 4950–6. 2000. doi:10.4049/jimmunol.165.9.4950. PMID 11046021.
- "Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease". Gut 50 (2): 186–90. 2002. doi:10.1136/gut.50.2.186. PMID 11788557.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production". J. Biol. Chem. 280 (18): 18056–62. 2005. doi:10.1074/jbc.M413297200. PMID 15760905.
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. 2005. doi:10.1038/nature03466. PMID 15815621. Bibcode: 2005Natur.434..724H.
- "Identification of IL-18RAP mRNA truncated splice variants in human testis and the other human tissues". Cytokine 39 (3): 178–83. 2008. doi:10.1016/j.cyto.2007.07.186. PMID 17897836.
External links
- IL18RAP+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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