Biology:CD164
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Sialomucin core protein 24 also known as endolyn or CD164 (cluster of differentiation 164) is a protein that in humans is encoded by the CD164 gene.[1][2] CD164 functions as a cell adhesion molecule.
Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play two key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor.[1]
References
- ↑ 1.0 1.1 "CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21". Blood 92 (3): 849–66. August 1998. doi:10.1182/blood.V92.3.849. PMID 9680353.
- ↑ "The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis". Blood 92 (8): 2613–28. October 1998. doi:10.1182/blood.V92.8.2613. PMID 9763543.
Further reading
- Zannettino AC (2001). "CD164.". J. Biol. Regul. Homeost. Agents 15 (4): 394–6. PMID 11862985.
- "A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression.". J. Biochem. 112 (5): 609–15. 1992. doi:10.1093/oxfordjournals.jbchem.a123948. PMID 1478919.
- "The Drosophila ortholog of the endolysosomal membrane protein, endolyn, regulates cell proliferation.". J. Cell. Biochem. 99 (5): 1380–96. 2006. doi:10.1002/jcb.20965. PMID 16924678.
- "Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn.". J. Biol. Chem. 276 (3): 2139–52. 2001. doi:10.1074/jbc.M007965200. PMID 11027692.
- "Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium". Nat. Genet. 41 (11): 1191–8. 2009. doi:10.1038/ng.466. PMID 19862010.
- "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics 7 (3): 499–508. 2008. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
- "Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164". Eur. J. Biochem. 265 (1): 466–72. 1999. doi:10.1046/j.1432-1327.1999.00777.x. PMID 10491205.
- "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. 2003. doi:10.1038/nature02055. PMID 14574404. Bibcode: 2003Natur.425..805M.
- "CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor". J. Immunol. 165 (2): 840–51. 2000. doi:10.4049/jimmunol.165.2.840. PMID 10878358.
- "Many sequence variants affecting diversity of adult human height". Nat. Genet. 40 (5): 609–15. 2008. doi:10.1038/ng.122. PMID 18391951.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. 2005. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- "The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis". BMC Cancer 6: 195. 2006. doi:10.1186/1471-2407-6-195. PMID 16859559.
- "Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells". Blood 109 (5): 1825–33. 2007. doi:10.1182/blood-2006-05-023028. PMID 17077324.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation". Cell Res. 15 (5): 325–35. 2005. doi:10.1038/sj.cr.7290301. PMID 15916720.
External links
- CD164+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CD164 genome location and CD164 gene details page in the UCSC Genome Browser.
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