Biology:RHD (gene)
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Rh blood group, D antigen also known as Rh polypeptide 1 (RhPI) or cluster of differentiation 240D (CD240D) is a protein that in humans is encoded by the RHD gene.[1]
The RHD gene codes for the RhD erythrocyte membrane protein that is the Rh factor antigen of the Rh blood group system.[2] RHD has sequence similarity to RHCE, RhAG, RhBG, and RhCG and these five genes constitute the Rh family. It was proposed that the erythrocyte Rh complex is a heterotrimer of RhAG, RhD, and RhCE protein subunits.[3] RhAG is a functional ammonia transporter and is required for normal cell surface expression of RhD and RhCE. Patients who lack RhD/RhCE/RhAG on the surface of their erythrocytes have hemolytic anemia. Antibodies to the RhD protein can cause Rh disease.
References
- ↑ "Entrez Gene: Rh blood group". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6007.
- ↑ "The structure and function of the Rh antigen complex". Seminars in Hematology 44 (1): 42–50. Jan 2007. doi:10.1053/j.seminhematol.2006.09.010. PMID 17198846.
- ↑ "Function of human Rh based on structure of RhCG at 2.1 A". Proceedings of the National Academy of Sciences of the United States of America 107 (21): 9638–43. May 2010. doi:10.1073/pnas.1003587107. PMID 20457942. Bibcode: 2010PNAS..107.9638G.
Further reading
- "Identification of RHD alleles with the potential of anti-D immunization among seemingly D- blood donors in Upper Austria". Transfusion 49 (4): 676–81. Apr 2009. doi:10.1111/j.1537-2995.2008.02046.x. PMID 19170995.
- "Weak D and DEL alleles detected by routine SNaPshot genotyping: identification of four novel RHD alleles". Transfusion 51 (2): 401–11. Feb 2011. doi:10.1111/j.1537-2995.2010.02830.x. PMID 20723165.
- "DCS-1, DCS-2, and DFV share amino acid substitutions at the extracellular RhD protein vestibule". Transfusion 48 (1): 25–33. Jan 2008. doi:10.1111/j.1537-2995.2007.01506.x. PMID 17900276.
- "[RHD gene polymorphism of RhD negative individuals in population of Fujian province]". Zhongguo Shi Yan Xue Ye Xue Za Zhi 16 (2): 435–8. Apr 2008. PMID 18426681.
- "Review: the molecular basis of the Rh blood group phenotypes". Immunohematology / American Red Cross 20 (1): 23–36. 2020. doi:10.21307/immunohematology-2019-419. PMID 15373666.
- "Hydrophobic cluster analysis and modeling of the human Rh protein three-dimensional structures". Transfusion Clinique et Biologique 13 (1–2): 70–84. 2006. doi:10.1016/j.tracli.2006.02.001. PMID 16584906.
- "Defining the Rh blood group antigens. Biochemistry and molecular genetics". Blood Reviews 8 (4): 199–212. Dec 1994. doi:10.1016/0268-960x(94)90108-2. PMID 7888828.
- "Admixture estimates for Caracas, Venezuela, based on autosomal, Y-chromosome, and mtDNA markers". Human Biology 79 (2): 201–13. Apr 2007. doi:10.1353/hub.2007.0032. PMID 18027815.
- "Molecular bases of unexpressed RHD alleles in Chinese D- persons". Transfusion 49 (8): 1655–60. Aug 2009. doi:10.1111/j.1537-2995.2009.02181.x. PMID 19392776.
- "Molecular determination of RHD zygosity: predicting risk of hemolytic disease of the fetus and newborn related to anti-D". Prenatal Diagnosis 30 (12–13): 1207–12. Dec 2010. doi:10.1002/pd.2652. PMID 21072752.
- "The influence of RhD phenotype on toxoplasmosis- and age-associated changes in personality profile of blood donors". Folia Parasitologica 57 (2): 143–50. Jun 2010. doi:10.14411/fp.2010.018. PMID 20608477.
- "Non-invasive foetal RHD genotyping via real-time PCR of foetal DNA from Chinese RhD-negative maternal plasma". European Journal of Clinical Investigation 39 (7): 607–17. Jul 2009. doi:10.1111/j.1365-2362.2009.02148.x. PMID 19545247.
- "Sequencing analysis of RHD intron 7 and 9". Transfusion and Apheresis Science 40 (3): 169–73. Jun 2009. doi:10.1016/j.transci.2009.03.004. PMID 19364677.
- "Growth-promoting effect of Rh(D) antibody on human pancreatic islet cells". The Journal of Clinical Endocrinology and Metabolism 93 (9): 3560–7. Sep 2008. doi:10.1210/jc.2008-0510. PMID 18544617.
- "Specific amino acid substitutions cause distinct expression of JAL (RH48) and JAHK (RH53) antigens in RhCE and not in RhD". Transfusion 50 (1): 267–9. Jan 2010. doi:10.1111/j.1537-2995.2009.02446.x. PMID 20233350.
- "Aberrant RNA splicing in RHD 7-9 exons of DEL individuals in Taiwan: a mechanism study". Biochimica et Biophysica Acta (BBA) - General Subjects 1800 (6): 565–73. Jun 2010. doi:10.1016/j.bbagen.2010.02.006. PMID 20188798.
- "[D antigen varieties and determination of Rhesus factor]". Klinicheskaia Laboratornaia Diagnostika (3): 17–9. Mar 2009. PMID 19388479.
- "Low risk of alloimmunization to the D antigen in D- orthotopic liver transplant recipients receiving D+ RBCs perioperatively". Transfusion 48 (12): 2653–5. Dec 2008. doi:10.1111/j.1537-2995.2008.01959.x. PMID 19055536.
- "The Rh blood group system: a review". Blood 95 (2): 375–87. Jan 2000. doi:10.1182/blood.V95.2.375. PMID 10627438.
- "The proximal cis-regulatory region of the RHD/RHCE promoter is 105 bp and contains a 55-bp core devoid of known binding motifs but necessary for transcription". Transfusion 49 (7): 1361–9. Jul 2009. doi:10.1111/j.1537-2995.2009.02162.x. PMID 19374729.
See also
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