Biology:F11 receptor

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Junctional adhesion molecule A is a protein that in humans is encoded by the F11R gene. It has also been designated as CD321 (cluster of differentiation 321).

Function

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple transcript variants encoding two different isoforms have been found for this gene.

Interactions

F11 receptor has been shown to interact with MLLT4, CASK and Tight junction protein 1.

Further reading

• "Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response". Trends in Immunology 24 (6): 327–34. Jun 2003. doi:10.1016/S1471-4906(03)00117-0. PMID 12810109. 
• "The JAM family of junctional adhesion molecules". Current Opinion in Cell Biology 15 (5): 525–30. Oct 2003. doi:10.1016/S0955-0674(03)00104-2. PMID 14519386. 
• "Junctional adhesion molecule 1 (JAM-1)". Journal of Biological Regulators and Homeostatic Agents 17 (4): 341–7. 2004. PMID 15065765. 
• "Activation of human platelets by a stimulatory monoclonal antibody". The Journal of Biological Chemistry 265 (17): 10042–8. Jun 1990. doi:10.1016/S0021-9258(19)38776-9. PMID 2351647. 
• "Identification and characterisation of human Junctional Adhesion Molecule (JAM)". Molecular Immunology 36 (17): 1175–88. Dec 1999. doi:10.1016/S0161-5890(99)00122-4. PMID 10698320. 
• "Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation". Blood 95 (8): 2600–9. Apr 2000. doi:10.1182/blood.V95.8.2600. PMID 10753840. 
• "Human junction adhesion molecule regulates tight junction resealing in epithelia". Journal of Cell Science 113 ( Pt 13) (13): 2363–74. Jul 2000. doi:10.1242/jcs.113.13.2363. PMID 10852816. 
• "Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1". The Journal of Biological Chemistry 275 (36): 27979–88. Sep 2000. doi:10.1074/jbc.M002363200. PMID 10856295. 
• "Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin". The Journal of Biological Chemistry 275 (27): 20520–6. Jul 2000. doi:10.1074/jbc.M905251199. PMID 10877843. 
• "Platelet agonist F11 receptor is a member of the immunoglobulin superfamily and identical with junctional adhesion molecule (JAM): regulation of expression in human endothelial cells and macrophages". IUBMB Life 50 (1): 51–6. Jul 2000. doi:10.1080/15216540050176593. PMID 11087121. 
• "Association of junctional adhesion molecule with calcium/calmodulin-dependent serine protein kinase (CASK/LIN-2) in human epithelial caco-2 cells". The Journal of Biological Chemistry 276 (12): 9291–6. Mar 2001. doi:10.1074/jbc.M006991200. PMID 11120739. 
• "Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody". Journal of Cell Science 114 (Pt 3): 539–47. Feb 2001. doi:10.1242/jcs.114.3.539. PMID 11171323. https://cdr.lib.unc.edu/downloads/df65vh931. 
• "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. Mar 2001. doi:10.1101/gr.GR1547R. PMID 11230166. 
• "Junction adhesion molecule is a receptor for reovirus". Cell 104 (3): 441–51. Feb 2001. doi:10.1016/S0092-8674(01)00231-8. PMID 11239401. 
• "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. Sep 2000. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
• "The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)". The EMBO Journal 20 (14): 3738–48. Jul 2001. doi:10.1093/emboj/20.14.3738. PMID 11447115. 
• "Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions". The Journal of Cell Biology 154 (3): 491–7. Aug 2001. doi:10.1083/jcb.200103047. PMID 11489913. 
• "Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule". The Journal of Biological Chemistry 277 (1): 455–61. Jan 2002. doi:10.1074/jbc.M109005200. PMID 11689568. 

External links

• KDR+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.