Biology:ART4
 Generic protein structure example |
Ecto-ADP-ribosyltransferase 4 is an enzyme that in humans is encoded by the ART4 gene.[1][2] ART4 has also been designated as CD297 (cluster of differentiation 297).
Function
This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinositol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.[2]
Blood group antigens
Several antigens have been recognised in this family. These are DO*A, DO*JO1, DO*A-WL, DO*DOYA, DO*B, DO*B-WL, DO*B-SH-Q149K, DO*B-(WL)-I175N, DO*HY1, DO*HY2 and DO*DOMR.
Clinical diagnostic
Clinical testing in patient care for Dombrock antigens follows published minimum quality and operational requirements,[3] similar to red cell genotyping for any of the other recognized blood group systems. Molecular analysis can identify gene variants (alleles) that may affect Dombrock antigens expression on the red cell membrane.
References
- ↑ "Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins". Genomics 39 (3): 370–6. Feb 1997. doi:10.1006/geno.1996.4520. PMID 9119374. http://dare.uva.nl/personal/pure/en/publications/two-novel-human-members-of-an-emerging-mammalian-gene-family-related-to-monoadpribosylating-bacterial-toxins(4140568d-5cb3-450b-b2f4-f7f3cff3006b).html.
- ↑ 2.0 2.1 "Entrez Gene: ART4 ADP-ribosyltransferase 4 (Dombrock blood group)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=420.
- ↑ "Association for the Advancement of Blood & Biotherapies (AABB). (2025). Standards for molecular testing for red cell, platelet, and neutrophil antigens, 7th ed. (ISBN: 978-1-56395-516-7)". https://www.aabb.org/aabb-store/product/standards-for-molecular-testing-for-red-cell-platelet-and-neutrophil-antigens-7th-edition-print-18521318.
Further reading
- "The Dombrock blood group system: a review". Transfusion 43 (1): 107–14. Jan 2003. doi:10.1046/j.1537-2995.2003.00283.x. PMID 12519438.
- "Genetics of the Dombrock blood group system". Journal of Medical Genetics 4 (1): 7–11. Mar 1967. doi:10.1136/jmg.4.1.7. PMID 6034522.
- "Dombrock blood group (DO): assignment to chromosome 12p". Human Genetics 98 (5): 518–21. Nov 1996. doi:10.1007/s004390050251. PMID 8882867.
- "Confirmation of the assignment of the Dombrock blood group locus (DO) to chromosome 12p: narrowing the boundaries to 12p12.3-p13.2". Vox Sanguinis 79 (1): 53–6. 2000. doi:10.1046/j.1423-0410.2000.7910053.x. PMID 10971215.
- "Identification of the dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family". Blood 96 (7): 2621–7. Oct 2000. doi:10.1182/blood.V96.7.2621. PMID 11001920.
- "Polymerase chain reaction with sequence-specific primers-based genotyping of the human Dombrock blood group DO1 and DO2 alleles and the DO gene frequencies in Chinese blood donors". Vox Sanguinis 81 (1): 49–51. Jul 2001. doi:10.1046/j.1423-0410.2001.00052.x. PMID 11520417. https://zenodo.org/record/1236484.
- "Insights into the Holley- and Joseph- phenotypes". Transfusion 42 (1): 52–8. Jan 2002. doi:10.1046/j.1537-2995.2002.00004.x. PMID 11896313.
- "Two new molecular bases for the Dombrock null phenotype". British Journal of Haematology 117 (3): 765–7. Jun 2002. doi:10.1046/j.1365-2141.2002.03524.x. PMID 12028057.
- "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse". Protein Science 11 (7): 1657–70. Jul 2002. doi:10.1110/ps.0200602. PMID 12070318.
- "Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1730 (3): 173–86. Sep 2005. doi:10.1016/j.bbaexp.2005.08.001. PMID 16140404.
External links
- ART4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human ART4 genome location and ART4 gene details page in the UCSC Genome Browser.
- Human DOK1 genome location and DOK1 gene details page in the UCSC Genome Browser.
- Dombrock blood group antigen NCBI Blood Group Antigen Gene Mutation Database
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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