Biology:ART4
 Generic protein structure example |
Ecto-ADP-ribosyltransferase 4 is an enzyme that in humans is encoded by the ART4 gene.[1][2] ART4 has also been designated as CD297 (cluster of differentiation 297).
Function
This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinositol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.[2]
Blood group antigens
Several antigens have been recognised in this family. These are DO*A, DO*JO1, DO*A-WL, DO*DOYA, DO*B, DO*B-WL, DO*B-SH-Q149K, DO*B-(WL)-I175N, DO*HY1, DO*HY2 and DO*DOMR.
References
- ↑ "Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins". Genomics 39 (3): 370–6. Feb 1997. doi:10.1006/geno.1996.4520. PMID 9119374. http://dare.uva.nl/personal/pure/en/publications/two-novel-human-members-of-an-emerging-mammalian-gene-family-related-to-monoadpribosylating-bacterial-toxins(4140568d-5cb3-450b-b2f4-f7f3cff3006b).html.
- ↑ 2.0 2.1 "Entrez Gene: ART4 ADP-ribosyltransferase 4 (Dombrock blood group)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=420.
Further reading
- "The Dombrock blood group system: a review". Transfusion 43 (1): 107–14. Jan 2003. doi:10.1046/j.1537-2995.2003.00283.x. PMID 12519438.
- "Genetics of the Dombrock blood group system". Journal of Medical Genetics 4 (1): 7–11. Mar 1967. doi:10.1136/jmg.4.1.7. PMID 6034522.
- "Dombrock blood group (DO): assignment to chromosome 12p". Human Genetics 98 (5): 518–21. Nov 1996. doi:10.1007/s004390050251. PMID 8882867.
- "Confirmation of the assignment of the Dombrock blood group locus (DO) to chromosome 12p: narrowing the boundaries to 12p12.3-p13.2". Vox Sanguinis 79 (1): 53–6. 2000. doi:10.1046/j.1423-0410.2000.7910053.x. PMID 10971215.
- "Identification of the dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family". Blood 96 (7): 2621–7. Oct 2000. doi:10.1182/blood.V96.7.2621. PMID 11001920.
- "Polymerase chain reaction with sequence-specific primers-based genotyping of the human Dombrock blood group DO1 and DO2 alleles and the DO gene frequencies in Chinese blood donors". Vox Sanguinis 81 (1): 49–51. Jul 2001. doi:10.1046/j.1423-0410.2001.00052.x. PMID 11520417. https://zenodo.org/record/1236484.
- "Insights into the Holley- and Joseph- phenotypes". Transfusion 42 (1): 52–8. Jan 2002. doi:10.1046/j.1537-2995.2002.00004.x. PMID 11896313.
- "Two new molecular bases for the Dombrock null phenotype". British Journal of Haematology 117 (3): 765–7. Jun 2002. doi:10.1046/j.1365-2141.2002.03524.x. PMID 12028057.
- "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse". Protein Science 11 (7): 1657–70. Jul 2002. doi:10.1110/ps.0200602. PMID 12070318.
- "Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1730 (3): 173–86. Sep 2005. doi:10.1016/j.bbaexp.2005.08.001. PMID 16140404.
External links
- ART4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human ART4 genome location and ART4 gene details page in the UCSC Genome Browser.
- Human DOK1 genome location and DOK1 gene details page in the UCSC Genome Browser.
- Dombrock blood group antigen NCBI Blood Group Antigen Gene Mutation Database
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
