Biology:CD109

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

CD109 (Cluster of Differentiation 109) is a human gene.

CD109 is a GPI-linked cell surface antigen expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T lymphoblasts, endothelial cells, and activated platelets (Lin et al., 2002). In addition, the platelet-specific Gov antigen system (HPA15), implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura, is carried by CD109 (Kelton et al., 1990; Lin et al., 2002).[supplied by OMIM]

See also

• Cluster of differentiation

Further reading

• "Platelet and granulocyte glycoprotein polymorphisms.". Transfusion Medicine (Oxford, England) 10 (3): 157–74. 2000. doi:10.1046/j.1365-3148.2000.00250.x. PMID 10972910. 
• "Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets.". Blood 77 (1): 84–93. 1991. doi:10.1182/blood.V77.1.84.84. PMID 1984805. 
• "Gova/b alloantigen system on human platelets.". Blood 75 (11): 2172–6. 1990. doi:10.1182/blood.V75.11.2172.2172. PMID 2346781. 
• "Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins.". Blood 99 (5): 1683–91. 2002. doi:10.1182/blood.V99.5.1683. PMID 11861284. 
• "A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens.". Blood 99 (5): 1692–8. 2002. doi:10.1182/blood.V99.5.1692. PMID 11861285. 
• "Antibody W7C5 defines a CD109 epitope expressed on CD34+ and CD34- hematopoietic and mesenchymal stem cell subsets.". Ann. N. Y. Acad. Sci. 996 (1): 227–30. 2003. doi:10.1111/j.1749-6632.2003.tb03250.x. PMID 12799300. Bibcode: 2003NYASA.996..227G. 
• "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. 2003. doi:10.1038/nature02055. PMID 14574404. Bibcode: 2003Natur.425..805M. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family.". Gene 327 (2): 171–83. 2004. doi:10.1016/j.gene.2003.11.025. PMID 14980714. 
• "CD109 expression in squamous cell carcinoma of the uterine cervix.". Pathol. Int. 55 (4): 165–9. 2005. doi:10.1111/j.1440-1827.2005.01807.x. PMID 15826242. 
• "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.". Mol. Cell. Proteomics 5 (2): 226–33. 2006. doi:10.1074/mcp.M500324-MCP200. PMID 16263699. 
• "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. 2006. doi:10.1021/pr0502065. PMID 16335952. 
• "Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes". FASEB J. 20 (9): 1525–7. 2006. doi:10.1096/fj.05-5229fje. PMID 16754747. 
• "The consensus coding sequences of human breast and colorectal cancers". Science 314 (5797): 268–74. 2006. doi:10.1126/science.1133427. PMID 16959974. Bibcode: 2006Sci...314..268S. 
• "CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells". Pathol. Int. 57 (5): 245–50. 2007. doi:10.1111/j.1440-1827.2007.02097.x. PMID 17493171. 

External links

• CD109+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CD109 genome location and CD109 gene details page in the UCSC Genome Browser.