Biology:IGSF8

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Short description: Protein-coding gene in the species Homo sapiens

A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene.[1][2][3] IGSF8 has also been designated as CD316 (cluster of differentiation 316). IGSF8 is an innate immune checkpoint that inhibits the cytotoxic activity of natural killer (NK) cells.[4] IGSF8 acts by binding to the Killer Ig-like Receptor KIR3DL2 (or, in mice, the analogous Klra9 receptor).[4] IGSF8 is frequently overexpressed relative to normal tissues in many cancers, included melanoma, urothelial carcinoma, and breast cancer,[4] and has been proposed as a potential therapeutic target in gliomas.[5] In normal tissues, IGSF8 is highly expressed in the brain, where it may contribute to the immune privilege of the central nervous system.[4]

Cancer biomarker

In gliomas, IGSF8 is strongly correlated with tumor grade and is a potential prognostic marker.[5] IGSF8 is enriched on ovarian cancer-derived extracellular vesicles and is a potential biomarker for the early detection of high grade serous ovarian cancer.[6]

References

  1. ↑ "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily". J Biol Chem 276 (44): 40545–40554. Oct 2001. doi:10.1074/jbc.M107338200. PMID 11504738. 
  2. ↑ "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins". J Immunol 167 (9): 5115–5121. Oct 2001. doi:10.4049/jimmunol.167.9.5115. PMID 11673522. 
  3. ↑ "Entrez Gene: IGSF8 immunoglobulin superfamily, member 8". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=93185. 
  4. ↑ 4.0 4.1 4.2 4.3 "IGSF8 is an innate immune checkpoint and cancer immunotherapy target". Cell 187 (11): 2703–2716.e23. May 2024. doi:10.1016/j.cell.2024.03.039. ISSN 0092-8674. PMID 38657602. 
  5. ↑ 5.0 5.1 "IGSF8 is a potential target for the treatment of gliomas" (in en). Asian Journal of Surgery 47 (9): 3883–3891. September 2024. doi:10.1016/j.asjsur.2024.02.118. PMID 38453613. 
  6. ↑ "Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer" (in en). Scientific Reports 13 (1). 2023-10-26. doi:10.1038/s41598-023-44050-5. ISSN 2045-2322. PMID 37884576. Bibcode: 2023NatSR..1318341T. 

Further reading




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