Chemistry:Adrogolide
Adrogolide (INN; developmental code names A-93431, ABT-431, and DAS-431), also known as adrogolide hydrochloride (USAN) in the case of the hydrochloride salt, is a dopamine D1-like receptor agonist which was under development for the treatment of Parkinson's disease, cognition disorders, and cocaine-related disorders but was never marketed.[1][2][3][4][5]
It is a chemically stable and rapidly converted diacetate ester prodrug of the highly selective dopamine D1 and D5 receptor full agonist A-86929.[4] The effects of adrogolide and A-86929 in animals and humans have been studied.[4][5] Side effects of adrogolide in humans included injection site reactions, asthenia, headache, nausea, vomiting, postural hypotension, vasodilation, and dizziness.[4]
Adrogolide was under development by Abbott Laboratories and DrugAbuse Sciences.[1][2][3] It reached phase 2 clinical trials for Parkinson's disease prior to the discontinuation of its development in 2001.[1][2][3] The drug is said to have been the first extensively characterized dopamine D1 receptor full agonist.[4]
See also
- List of investigational Parkinson's disease drugs
- List of investigational substance-related disorder drugs
- Dihydrexidine (DAR-0100; IP-202)
References
- ↑ 1.0 1.1 1.2 "Adrogolide". 30 January 2013. https://adisinsight.springer.com/drugs/800006590.
- ↑ 2.0 2.1 2.2 "Delving into the Latest Updates on Adrogolide Hydrochloride with Synapse". 15 November 2025. https://synapse.patsnap.com/drug/e927cbe62128495b9d94fd156114726a.
- ↑ 3.0 3.1 3.2 "Adrogolide Drug Profile". 1 January 1900. https://pryzm.ozmosi.com/product/2534.
- ↑ 4.0 4.1 4.2 4.3 4.4 "Adrogolide HCl (ABT-431; DAS-431), a prodrug of the dopamine D1 receptor agonist, A-86929: preclinical pharmacology and clinical data". CNS Drug Rev 7 (3): 305–316. 2001. doi:10.1111/j.1527-3458.2001.tb00201.x. PMID 11607045.
- ↑ 5.0 5.1 Unattributed (2000). "Information Update Volume 1-24, Number 8". Drugs of the Future 25 (8): 843–888 (844–844). https://access.portico.org/Portico/auView?auId=ark%3A%2F27927%2Fpjbf78x656n. "ABT-431. Adrogolide Hydrochloride [...]".
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