Chemistry:MCHB-1
From HandWiki
Short description: Chemical compound
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| Formula | C28H37N3O2 |
| Molar mass | 447.623 g·mol−1 |
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MCHB-1 is a benzimidazole derived drug which was researched as an analgesic but never developed for medical use. It acts as a potent agonist of the CB2 receptor, with an EC50 of 0.52nM at CB2, and ~30x selectivity over CB1 (Ki of 110nM at CB1 vs 3.7nM at CB2).[1][2] It has been sold online as a designer drug, first being identified in Germany in December 2013.[3]
See also
- AZD1940
- AZ-11713908
- BIM-018
- Etazen
- Etoacetazene
References
- ↑ "Novel benzimidazole derivatives as selective CB2 agonists". Bioorganic & Medicinal Chemistry Letters 18 (13): 3695–700. July 2008. doi:10.1016/j.bmcl.2008.05.073. PMID 18522867.
- ↑ "A peripherally restricted cannabinoid receptor agonist produces robust anti-nociceptive effects in rodent models of inflammatory and neuropathic pain". Pain 151 (2): 337–44. November 2010. doi:10.1016/j.pain.2010.07.019. PMID 20696525.
- ↑ "Two thiazolylindoles and a benzimidazole: novel compounds on the designer drug market with potential cannabinoid receptor activity". Forensic Science International 249: 133–47. April 2015. doi:10.1016/j.forsciint.2015.01.014. PMID 25698514.
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