Chemistry:Fentanyl azepane
From HandWiki
Short description: Chemical compound
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| Formula | C23H30N2O |
| Molar mass | 350.506 g·mol−1 |
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Fentanyl azepane (Fentanyl azepane homologue) is an opioid derivative which is a homologue of fentanyl, where the central piperidine ring has been expanded to an azepane ring. It is many times less potent than fentanyl itself, being only slightly stronger than morphine, but is still more potent than the ring-contracted pyrrolidine derivative, as well as other related compounds such as benzylfentanyl and ethoheptazine. The β-hydroxy derivative is slightly more potent again, as with betahydroxyfentanyl.[1][2][3]
See also
- 3-Methylfentanyl
- Fentanyl tropane
- Homofentanyl
- Secofentanyl
- Proheptazine
- List of fentanyl analogues
References
- ↑ "4-Anilidopiperidine analgesics. 3. 1-Substituted 4-(propananilido)perhydroazepines as ring-expanded analogues". Journal of Medicinal Chemistry 23 (8): 895–9. August 1980. doi:10.1021/jm00182a016. PMID 7190616.
- ↑ "Investigation of the synthesis and analgesic activity of 1-substituted 4-(propananilido) perhydroazepines.". Journal of Heterocyclic Chemistry 29 (4): 779–786. 1992. doi:10.1002/jhet.5570290417.
- ↑ "Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications". Future Medicinal Chemistry 6 (4): 385–412. March 2014. doi:10.4155/fmc.13.215. PMID 24635521.
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