Biology:Integrin alpha 3
 Generic protein structure example |
Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene.[1][2] ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.
ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular matrix proteins.
Alternative names
The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').[3]
Interactions
CD49c has been shown to interact with:
References
- ↑ "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen". J Cell Biol 115 (1): 257–66. October 1991. doi:10.1083/jcb.115.1.257. PMID 1655803.
- ↑ "Genomic organization of the human alpha 3 integrin subunit gene". Biochem Biophys Res Commun 248 (3): 896–8. September 1998. doi:10.1006/bbrc.1998.9071. PMID 9704023.
- ↑ "Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3675.
- ↑ "CD9 is expressed on human endometrial epithelial cells in association with integrins alpha(6), alpha(3) and beta(1)". Mol. Hum. Reprod. 6 (3): 252–7. March 2000. doi:10.1093/molehr/6.3.252. PMID 10694273.
- ↑ "CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5". Mol. Hum. Reprod. 5 (2): 162–7. February 1999. doi:10.1093/molehr/5.2.162. PMID 10065872.
- ↑ "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. 275 (43): 33669–78. October 2000. doi:10.1074/jbc.M002519200. PMID 10906324.
- ↑ "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell Sci. 113 (13): 2385–97. July 2000. doi:10.1242/jcs.113.13.2385. PMID 10852818.
- ↑ "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. 272 (46): 29181–9. November 1997. doi:10.1074/jbc.272.46.29181. PMID 9360996.
Further reading
- "Integrins: cell adhesives and modulators of cell function.". Histochem. J. 25 (7): 469–77. 1993. doi:10.1007/BF00159282. PMID 8407358.
- "Alternatively spliced variants: a new view of the integrin cytoplasmic domain.". Matrix Biol. 16 (4): 185–93. 1998. doi:10.1016/S0945-053X(97)90007-X. PMID 9402008.
External links
- CD49c+antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
- ITGA3 Info with links in the Cell Migration Gateway
- Human ITGA3 genome location and ITGA3 gene details page in the UCSC Genome Browser.
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