Biology:JAM2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene.[1][2][3] JAM2 has also been designated as CD322 (cluster of differentiation 322).
Function
Tight junctions represent one mode of cell-to-cell adhesion in endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.[3]
It is purported to promote lymphocyte transendothelial migration.[4] It might also be involved with endothelial cell polarity, by associating to cell polarity protein PARD3 (PAR-3), together with JAM3.[5]
Interactions
JAM2 has been shown to interact with PARD3.[5]
It also interacts with the integrin dimer VLA-4 (also called α4β1).[6]
References
- ↑ "Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells". J Biol Chem 275 (25): 19139–45. Aug 2000. doi:10.1074/jbc.M003189200. PMID 10779521.
- ↑ "A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions". J Biol Chem 275 (44): 34750–6. Nov 2000. doi:10.1074/jbc.M002718200. PMID 10945976.
- ↑ 3.0 3.1 "Entrez Gene: JAM2 junctional adhesion molecule 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=58494.
- ↑ "Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration". Blood 100 (7): 2479–86. October 2002. doi:10.1182/blood-2001-11-0098. PMID 12239159.
- ↑ 5.0 5.1 "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell Sci. 116 (Pt 19): 3879–91. October 2003. doi:10.1242/jcs.00704. PMID 12953056.
- ↑ "JAM2 interacts with alpha4beta1. Facilitation by JAM3". J. Biol. Chem. 277 (31): 27589–92. August 2002. doi:10.1074/jbc.C200331200. PMID 12070135.
Further reading
- Muller WA (2003). "Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.". Trends Immunol. 24 (6): 327–34. doi:10.1016/S1471-4906(03)00117-0. PMID 12810109.
- Bazzoni G (2004). "The JAM family of junctional adhesion molecules.". Curr. Opin. Cell Biol. 15 (5): 525–30. doi:10.1016/S0955-0674(03)00104-2. PMID 14519386.
- "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. 2000. doi:10.1038/35012518. PMID 10830953. Bibcode: 2000Natur.405..311H. https://archive-ouverte.unige.ch/unige:8796.
- "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- "Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor.". J. Biol. Chem. 276 (49): 45826–32. 2002. doi:10.1074/jbc.M105972200. PMID 11590146.
- "Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3.". J. Immunol. 168 (4): 1618–26. 2002. doi:10.4049/jimmunol.168.4.1618. PMID 11823489.
- "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis.". Genomics 79 (6): 833–43. 2002. doi:10.1006/geno.2002.6782. PMID 12036298.
- "JAM2 interacts with alpha4beta1. Facilitation by JAM3.". J. Biol. Chem. 277 (31): 27589–92. 2002. doi:10.1074/jbc.C200331200. PMID 12070135.
- "Junctional adhesion molecules and interendothelial junctions.". Cells Tissues Organs (Print) 172 (3): 152–60. 2004. doi:10.1159/000066967. PMID 12476045.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity.". J. Cell Sci. 116 (Pt 19): 3879–91. 2004. doi:10.1242/jcs.00704. PMID 12953056. https://archive-ouverte.unige.ch/unige:11233/ATTACHMENT01.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. 2005. doi:10.1110/ps.04682504. PMID 15340161.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. 2006. doi:10.1021/pr0502065. PMID 16335952.
External links
- JAM2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: Q9JI59 (Mouse Junctional adhesion molecule B) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
