Biology:Opioidergic
From HandWiki
Structural correlation between met-enkephalin, an opioid peptide, (left) and morphine, an opiate drug, (right)
An opioidergic agent (or drug) is a chemical which functions to directly modulate the opioid neuropeptide systems (i.e., endorphin, enkephalin, dynorphin, nociceptin) in the body or brain. Examples include opioid analgesics such as morphine and opioid antagonists such as naloxone. Opioidergics also comprise allosteric modulators and enzyme affecting agents like enkephalinase inhibitors.
Allosteric modulators
- BMS-986121: μ-PAM[1]
- BMS-986122: μ-PAM[1]
- Ignavine[2]
- Oxytocin: μ-PAM[3]
- δ-PAM (see reference)[4]
- Cannabidiol[5]
- Tetrahydrocannabinol[5]
- Sodium (Na+) [6]
See also
- List of opioids
- Adenosinergic
- Adrenergic
- Cannabinoidergic
- Cholinergic
- Dopaminergic
- GABAergic
- Glycinergic
- Histaminergic
- Melatonergic
- Monoaminergic
- Serotonergic
References
- ↑ 1.0 1.1 "Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor". Proc. Natl. Acad. Sci. U.S.A. 110 (26): 10830–5. June 2013. doi:10.1073/pnas.1300393110. PMID 23754417. Bibcode: 2013PNAS..11010830B.
- ↑ "Ignavine: a novel allosteric modulator of the μ opioid receptor". Sci Rep 6: 31748. August 2016. doi:10.1038/srep31748. PMID 27530869. Bibcode: 2016NatSR...631748O.
- ↑ "Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator". J. Pharmacol. Sci. 137 (1): 67–75. May 2018. doi:10.1016/j.jphs.2018.04.002. PMID 29716811.
- ↑ "Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ-Opioid Receptor". J. Med. Chem. 58 (10): 4220–9. 2015. doi:10.1021/acs.jmedchem.5b00007. PMID 25901762.
- ↑ 5.0 5.1 "Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors". Naunyn Schmiedebergs Arch. Pharmacol. 372 (5): 354–61. February 2006. doi:10.1007/s00210-006-0033-x. PMID 16489449.
- ↑ "Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions". Biochemistry 53 (31): 5140–9. 2014. doi:10.1021/bi5006915. PMID 25073009.
 |  |
