Biology:CD160
 Generic protein structure example |
CD160 antigen is a protein that in humans is encoded by the CD160 gene.[1][2][3]
CD160 is a 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.[3]
Clinical significance
CD160 is a ligand for HVEM, and considered a proposed immune checkpoint inhibitor with anti-cancer activity along with anti- PD-1 antibodies.[4] CD160 has also been proposed as a potential new target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs.[5]
Related gene problems
See also
References
- ↑ "Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes". J Immunol 161 (6): 2780–90. Oct 1998. doi:10.4049/jimmunol.161.6.2780. PMID 9743336.
- ↑ "Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells". J Immunol 162 (3): 1223–6. Apr 1999. doi:10.4049/jimmunol.162.3.1223. PMID 9973372.
- ↑ 3.0 3.1 "Entrez Gene: CD160 CD160 molecule". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11126.
- ↑ Stecher, Carmen; Battin, Claire; Leitner, Judith; Zettl, Markus; Grabmeier-Pfistershammer, Katharina; H?ller, Christoph; Zlabinger, Gerhard J.; Steinberger, Peter (22 May 2017). "PD-1 Blockade Promotes Emerging Checkpoint Inhibitors in Enhancing T Cell Responses to Allogeneic Dendritic Cells". Frontiers in Immunology 8: 572. doi:10.3389/fimmu.2017.00572. PMID 28588576.
- ↑ Chabot, Sophie; Jabrane-Ferrat, Nabila; Bigot, Karine; Tabiasco, Julie; Provost, Alexandra; Golzio, Muriel; Noman, Muhammad Zaeem; Giustiniani, J?r?me et al. (9 May 2011). "A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor". The Journal of Experimental Medicine 208 (5): 973–986. doi:10.1084/jem.20100810. PMID 21482699.
- ↑ "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome". Am. J. Hum. Genet. 80 (2): 232–40. February 2007. doi:10.1086/510919. PMID 17236129.
Further reading
- "BY55 monoclonal antibody delineates within human cord blood and bone marrow lymphocytes distinct cell subsets mediating cytotoxic activity.". Proc. Natl. Acad. Sci. U.S.A. 91 (19): 9136–40. 1994. doi:10.1073/pnas.91.19.9136. PMID 8090781. Bibcode: 1994PNAS...91.9136B.
- "BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression.". Int. Immunol. 14 (5): 445–51. 2002. doi:10.1093/intimm/14.5.445. PMID 11978774.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Cytolytic activity and regulatory functions of inhibitory NK cell receptor-expressing T cells expanded from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells.". Blood 104 (3): 768–74. 2004. doi:10.1182/blood-2003-11-3870. PMID 15073036.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset.". J. Immunol. 173 (9): 5349–54. 2004. doi:10.4049/jimmunol.173.9.5349. PMID 15494480.
- "Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation.". J. Invest. Dermatol. 127 (5): 1161–6. 2007. doi:10.1038/sj.jid.5700680. PMID 17218942.
- "A soluble form of the MHC class I-specific CD160 receptor is released from human activated NK lymphocytes and inhibits cell-mediated cytotoxicity.". J. Immunol. 178 (3): 1293–300. 2007. doi:10.4049/jimmunol.178.3.1293. PMID 17237375.
External links
- CD160+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CD160 genome location and CD160 gene details page in the UCSC Genome Browser.
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