Biology:APRIL (protein)
 Generic protein structure example |
A proliferation-inducing ligand (APRIL), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a protein of the TNF superfamily recognized by the cell surface receptor TACI.[1][2] It is encoded by the TNFSF13 gene.[2]
Nomenclature
In the cluster of differentiation terminology, APRIL is designated CD256.
Function
The protein encoded by this gene is a member of the tumor necrosis factor ligand (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important role for APRIL in the long-term survival of plasma cells in the bone marrow. Mice deficient in APRIL have normal immune system development.[3] However, APRIL-deficient mice have also been reported to possess a reduced ability to support plasma cell survival.[4] In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM.[5] Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Interactions
TNFSF13 has been shown to interact with TNFRSF13B[6] and B-cell activating factor.[7]
Clinical significance
APRIL is being explored as a target for autoimmune diseases and B cell malignancies.[8] At least one anti-APRIL monoclonal antibody has been announced to enter phase I clinical trials for multiple myeloma.[9]
References
- ↑ "APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth". The Journal of Experimental Medicine 188 (6): 1185–90. September 1998. doi:10.1084/jem.188.6.1185. PMID 9743536.
- ↑ 2.0 2.1 "Entrez Gene: TNFSF13 tumor necrosis factor (ligand) superfamily, member 13". National Library of Medicine. 10 October 2023. https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8741.
- ↑ "APRIL-deficient mice have normal immune system development". Molecular and Cellular Biology 24 (3): 997–1006. February 2004. doi:10.1128/MCB.24.3.997-1006.2004. PMID 14729948.
- ↑ "APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells". Blood 111 (5): 2755–64. March 2008. doi:10.1182/blood-2007-09-110858. PMID 18180376.
- ↑ "APRIL, a new member of the tumor necrosis factor family, modulates death ligand-induced apoptosis". Cell Death and Differentiation 8 (4): 403–10. April 2001. doi:10.1038/sj.cdd.4400827. PMID 11550092.
- ↑ "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". The Journal of Biological Chemistry 275 (45): 35478–85. November 2000. doi:10.1074/jbc.M005224200. PMID 10956646.
- ↑ "BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases". Journal of Immunology 169 (8): 4314–21. October 2002. doi:10.4049/jimmunol.169.8.4314. PMID 12370363.
- ↑ Ryan, Maureen C.; Grewal, Iqbal S. (2009-01-01). "Targeting of BAFF and APRIL for Autoimmunity and Oncology". in Grewal, Iqbal S.. Therapeutic Targets of the TNF Superfamily. Advances in Experimental Medicine and Biology. 647. New York: Springer. pp. 52–63. doi:10.1007/978-0-387-89520-8_4. ISBN 978-0-387-89519-2.
- ↑ "Development of a first in class APRIL fully blocking antibody BION-1301 for the treatment of multiple myeloma". AACR 2017 Proceedings. April 2017. http://www.abstractsonline.com/pp8/#!/4292/presentation/6077.
Further reading
- "BAFF, APRIL and their receptors: structure, function and signaling". Seminars in Immunology 18 (5): 263–75. October 2006. doi:10.1016/j.smim.2006.04.006. PMID 16914324. https://serval.unil.ch/resource/serval:BIB_89872BC6E950.P001/REF.pdf.
- "BAFF, APRIL and human B cell disorders". Seminars in Immunology 18 (5): 305–17. October 2006. doi:10.1016/j.smim.2006.04.004. PMID 16916610.
- "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells". Seminars in Immunology 18 (5): 297–304. October 2006. doi:10.1016/j.smim.2006.07.001. PMID 16919470.
- "The role of the BAFF/APRIL system on T cell function". Seminars in Immunology 18 (5): 284–9. October 2006. doi:10.1016/j.smim.2006.04.005. PMID 16931039.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens". Journal of Leukocyte Biology 65 (5): 680–3. May 1999. doi:10.1002/jlb.65.5.680. PMID 10331498.
- "Physical map of 17p13 and the genes adjacent to p53". Genomics 63 (1): 60–8. January 2000. doi:10.1006/geno.1999.6062. PMID 10662545.
- "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death". Cancer Research 60 (4): 1021–7. February 2000. PMID 10706119.
- "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". The Journal of Biological Chemistry 275 (45): 35478–85. November 2000. doi:10.1074/jbc.M005224200. PMID 10956646.
- "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity". Nature Immunology 1 (3): 252–6. September 2000. doi:10.1038/79802. PMID 10973284.
- "Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase". EMBO Reports 2 (10): 945–51. October 2001. doi:10.1093/embo-reports/kve198. PMID 11571266.
- "APRIL modulates B and T cell immunity". The Journal of Clinical Investigation 109 (12): 1587–98. June 2002. doi:10.1172/JCI15034. PMID 12070306.
- "DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL". Nature Immunology 3 (9): 822–9. September 2002. doi:10.1038/ni829. PMID 12154359.
- "BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases". Journal of Immunology 169 (8): 4314–21. October 2002. doi:10.4049/jimmunol.169.8.4314. PMID 12370363.
- "An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein". The EMBO Journal 21 (21): 5711–20. November 2002. doi:10.1093/emboj/cdf565. PMID 12411489.
External links
- TNFSF13+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human TNFSF13 genome location and TNFSF13 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
