Biology:SIGLEC7

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Sialic acid-binding Ig-like lectin 7 is a protein that in humans is encoded by the SIGLEC7 gene. SIGLEC7 has also been designated as CD328 (cluster of differentiation 328).

Further reading

• "SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases.". J. Biol. Chem. 269 (19): 14081–7. 1994. doi:10.1016/S0021-9258(17)36757-1. PMID 8188688. 
• "Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells.". J. Exp. Med. 190 (6): 793–802. 1999. doi:10.1084/jem.190.6.793. PMID 10499918. 
• "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.". J. Biol. Chem. 274 (42): 30202–8. 1999. doi:10.1074/jbc.274.42.30202. PMID 10514511. 
• "Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells.". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 15091–6. 2000. doi:10.1073/pnas.96.26.15091. PMID 10611343. 
• "Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.". Glycobiology 10 (4): 431–8. 2000. doi:10.1093/glycob/10.4.431. PMID 10764831. 
• "Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression.". FEBS Lett. 498 (1): 116–20. 2001. doi:10.1016/S0014-5793(01)02476-0. PMID 11389909. 
• "Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 surface receptors". Progress in Basic and Clinical Immunology. Advances in Experimental Medicine and Biology. 495. 2001. pp. 55–61. doi:10.1007/978-1-4615-0685-0_8. ISBN 978-1-4613-5194-8. 
• "Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes.". Gene 286 (2): 259–70. 2002. doi:10.1016/S0378-1119(02)00432-8. PMID 11943481. 
• "High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family.". J. Biol. Chem. 278 (5): 3372–7. 2003. doi:10.1074/jbc.M210602200. PMID 12438315. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms.". Eur. J. Immunol. 33 (6): 1642–8. 2003. doi:10.1002/eji.200323693. PMID 12778482. 
• "Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1.". Acta Crystallogr. D 60 (Pt 2): 401–3. 2004. doi:10.1107/S0907444903028439. PMID 14747738. 
• "Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9.". J. Biol. Chem. 279 (41): 43117–25. 2004. doi:10.1074/jbc.M403538200. PMID 15292262. 
• "The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells.". J. Immunol. 173 (11): 6841–9. 2005. doi:10.4049/jimmunol.173.11.6841. PMID 15557178. 
• "Characterization of inhibitory signaling motifs of the natural killer cell receptor Siglec-7: attenuated recruitment of phosphatases by the receptor is attributed to two amino acids in the motifs.". Glycobiology 15 (7): 667–76. 2005. doi:10.1093/glycob/cwi048. PMID 15703304. 
• "The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design.". Biochem. J. 397 (2): 271–8. 2006. doi:10.1042/BJ20060103. PMID 16623661. 
• "Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides.". Biochemistry Mosc. 71 (5): 496–504. 2006. doi:10.1134/S0006297906050051. PMID 16732727. 
• "Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors.". Leuk. Res. 31 (2): 211–20. 2007. doi:10.1016/j.leukres.2006.05.026. PMID 16828866. 

External links

• SIGLEC7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.