Biology:LAIR1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene.[1][2] LAIR1 has also been designated as CD305 (cluster of differentiation 305).
Function
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells.[3] Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.[2]
Interactions
LAIR1 has been shown to interact with PTPN11[1][4] and PTPN6.[1][4][5][6][7]
References
- ↑ 1.0 1.1 1.2 "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity 7 (2): 283–90. September 1997. doi:10.1016/S1074-7613(00)80530-0. PMID 9285412.
- ↑ 2.0 2.1 "Entrez Gene: LAIR1 leukocyte-associated immunoglobulin-like receptor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3903.
- ↑ "Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling". European Journal of Immunology 29 (10): 3160–7. October 1999. doi:10.1002/(SICI)1521-4141(199910)29:10<3160::AID-IMMU3160>3.0.CO;2-S. PMID 10540327.
- ↑ 4.0 4.1 "FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells". J. Immunol. 165 (3): 1197–209. August 2000. doi:10.4049/jimmunol.165.3.1197. PMID 10903717.
- ↑ "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. 166 (3): 1763–70. February 2001. doi:10.4049/jimmunol.166.3.1763. PMID 11160222.
- ↑ "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta". J. Biol. Chem. 275 (6): 4467–74. February 2000. doi:10.1074/jbc.275.6.4467. PMID 10660620.
- ↑ "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells". J. Biol. Chem. 275 (23): 17440–6. June 2000. doi:10.1074/jbc.M001313200. PMID 10764762.
Further reading
- "Why so many coinhibitory receptors?". Scand. J. Immunol. 50 (1): 10–3. 1999. doi:10.1046/j.1365-3083.1999.00580.x. PMID 10404045.
- "LAIR-1, a Widely Distributed Human ITIM-Bearing Receptor on Hematopoietic Cells". Immunoreceptor Tyrosine-based Inhibition Motifs. Current Topics in Microbiology 244 and Immunology. 244. 1999. 151–7. doi:10.1007/978-3-642-58537-1_13. ISBN 978-3-540-65789-7.
- "Leukocyte associated Ig-like receptor (LAIR)". J. Biol. Regul. Homeost. Agents 17 (4): 330–3. 2004. PMID 15065762.
- "p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor". Eur. J. Immunol. 28 (7): 2086–91. 1998. doi:10.1002/(SICI)1521-4141(199807)28:07<2086::AID-IMMU2086>3.0.CO;2-T. PMID 9692876.
- "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells". J. Immunol. 162 (10): 5800–4. 1999. doi:10.4049/jimmunol.162.10.5800. PMID 10229813.
- "Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias". Eur. J. Immunol. 30 (10): 2751–8. 2000. doi:10.1002/1521-4141(200010)30:10<2751::AID-IMMU2751>3.0.CO;2-L. PMID 11069054.
- "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. 166 (3): 1763–70. 2001. doi:10.4049/jimmunol.166.3.1763. PMID 11160222.
- "Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions". Hum. Immunol. 63 (7): 534–46. 2002. doi:10.1016/S0198-8859(02)00409-3. PMID 12072189.
- "Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells". J. Clin. Immunol. 23 (2): 141–5. 2003. doi:10.1023/A:1022580929226. PMID 12757266.
- "Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment". Int. Immunol. 15 (11): 1349–58. 2003. doi:10.1093/intimm/dxg134. PMID 14565933.
- "Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection". Blood 103 (6): 2180–6. 2004. doi:10.1182/blood-2003-07-2375. PMID 14604962.
External links
- LAIR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: Q6GTX8 (Leukocyte-associated immunoglobulin-like receptor 1) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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