Biology:CD3D

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene.

Interactions

CD3D has been shown to interact with CD8A.

See also

• CD3 (immunology)
• Cluster of differentiation

Further reading

• "Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain.". Int. Immunol. 7 (8): 1237–41. 1996. doi:10.1093/intimm/7.8.1237. PMID 7495730. 
• Li CJ (2007). "Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference.". J. Cell. Physiol. 209 (3): 695–700. doi:10.1002/jcp.20817. PMID 17001685. 
• "Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon, delta proteins.". J. Exp. Med. 175 (4): 1055–66. 1992. doi:10.1084/jem.175.4.1055. PMID 1372642. 
• "The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope.". Immunol. Lett. 33 (3): 307–14. 1992. doi:10.1016/0165-2478(92)90078-3. PMID 1385321. 
• "The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes.". EMBO J. 10 (4): 903–12. 1991. doi:10.1002/j.1460-2075.1991.tb08023.x. PMID 1826255. 
• "Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3.". Int. Immunol. 3 (4): 353–7. 1991. doi:10.1093/intimm/3.4.353. PMID 1831653. 
• "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx.". Cell. Immunol. 137 (1): 1–13. 1991. doi:10.1016/0008-8749(91)90051-C. PMID 1832084. 
• "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.". J. Clin. Invest. 86 (6): 2117–24. 1991. doi:10.1172/JCI114950. PMID 1979339. 
• "Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV.". Folia Biol. (Praha) 36 (1): 71–7. 1990. PMID 2111780. 
• "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex.". Eur. J. Immunol. 20 (2): 299–305. 1990. doi:10.1002/eji.1830200211. PMID 2138083. 
• "Dephosphorylation of the human T lymphocyte CD3 antigen.". Eur. J. Biochem. 181 (1): 55–65. 1989. doi:10.1111/j.1432-1033.1989.tb14693.x. PMID 2540970. 
• "Physical linkage of three CD3 genes on human chromosome 11.". EMBO J. 6 (10): 2953–7. 1988. doi:10.1002/j.1460-2075.1987.tb02600.x. PMID 2826124. 
• "Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein.". Nature 314 (6011): 542–4. 1985. doi:10.1038/314542a0. PMID 2859526. Bibcode: 1985Natur.314..542V. 
• "Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex.". Proc. Natl. Acad. Sci. U.S.A. 83 (9): 2944–8. 1986. doi:10.1073/pnas.83.9.2944. PMID 2939461. Bibcode: 1986PNAS...83.2944V. 
• "Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family.". Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7649–53. 1987. doi:10.1073/pnas.84.21.7649. PMID 3478717. Bibcode: 1987PNAS...84.7649G. 
• "T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells.". EMBO J. 5 (6): 1245–52. 1986. doi:10.1002/j.1460-2075.1986.tb04353.x. PMID 3488209. 
• "Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex.". Nature 312 (5993): 413–8. 1985. doi:10.1038/312413a0. PMID 6095101. Bibcode: 1984Natur.312..413V. 
• "Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120.". AIDS Res. Hum. Retroviruses 9 (10): 945–55. 1994. doi:10.1089/aid.1993.9.945. PMID 7506554. https://zenodo.org/record/1235235. 
• "An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex.". Cell. Immunol. 156 (2): 286–95. 1994. doi:10.1006/cimm.1994.1175. PMID 7517794. 

External links

• Human CD3D genome location and CD3D gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: P04234 (T-cell surface glycoprotein CD3 delta chain) at the PDBe-KB.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human T-cell surface glycoprotein CD3 delta chain (CD3D)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.