Biology:CD300A

Short description: Human gene

Generic protein structure example

CD300A (Cluster of Differentiation 300A) is a human gene.

The CMRF35 antigen (CMRF35A; MIM 606786), which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes. CMRF35H is recognized by the same antibody and is distinct from CMRF35 (Green et al., 1998).[supplied by OMIM]

See also

• Cluster of differentiation

Further reading

• "CMRF-35A, CMRF-35H: potential new CD.". J. Biol. Regul. Homeost. Agents 16 (3): 233–5. 2003. PMID 12456026. 
• "The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling.". Mol. Immunol. 45 (1): 253–8. 2007. doi:10.1016/j.molimm.2007.05.006. PMID 17588661. 
• "The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells.". J. Immunol. 175 (12): 7989–95. 2006. doi:10.4049/jimmunol.175.12.7989. PMID 16339535. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17.". Tissue Antigens 55 (2): 101–9. 2000. doi:10.1034/j.1399-0039.2000.550201.x. PMID 10746781. 
• "Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells.". Eur. J. Immunol. 29 (10): 3148–59. 1999. doi:10.1002/(SICI)1521-4141(199910)29:10<3148::AID-IMMU3148>3.0.CO;2-L. PMID 10540326. 
• "The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor.". Int. Immunol. 10 (7): 891–9. 1998. doi:10.1093/intimm/10.7.891. PMID 9701027. 
• "Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor.". Eur. J. Immunol. 22 (5): 1157–63. 1992. doi:10.1002/eji.1830220508. PMID 1349532. 

External links

• CD300A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• CD300a, Bernholtz - The Possible End to Asthma - The Future of Things article
• Human CD300A genome location and CD300A gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q9UGN4 (Human CMRF35-like molecule 8 (CD300A)) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.