Biology:Basal cell adhesion molecule

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Basal cell adhesion molecule, also known as Lutheran antigen, is a plasma membrane glycoprotein that in humans is encoded by the BCAM gene. BCAM has also recently been designated CD239 (cluster of differentiation 239).

Function

Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

BCAM has been shown to interact with Laminin, alpha 5. BCAM has also been shown to promote the metastasis of ovarian cancer.

Further reading

• "The Lutheran glycoprotein: a multifunctional adhesion receptor.". Transfusion 46 (4): 668–77. 2006. doi:10.1111/j.1537-2995.2006.00779.x. PMID 16584446. 
• "The chromosome 19 linkage group LDLR, C3, LW, APOC2, LU, SE in man.". Ann. Hum. Genet. 52 (Pt 2): 137–44. 1989. doi:10.1111/j.1469-1809.1988.tb01089.x. PMID 2907851. 
• "The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver.". Proc. Natl. Acad. Sci. U.S.A. 92 (12): 5496–500. 1995. doi:10.1073/pnas.92.12.5496. PMID 7777537. Bibcode: 1995PNAS...92.5496P. 
• "Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily.". Cancer Res. 54 (22): 5761–5. 1994. PMID 7954395. 
• "A unique gene encodes spliceoforms of the B-cell adhesion molecule cell surface glycoprotein of epithelial cancer and of the Lutheran blood group glycoprotein.". Blood 88 (5): 1865–72. 1996. doi:10.1182/blood.V88.5.1865.1865. PMID 8781446. 
• "Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms.". Blood 89 (11): 4219–25. 1997. doi:10.1182/blood.V89.11.4219. PMID 9166867. 
• "Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism.". Blood 89 (12): 4608–16. 1997. doi:10.1182/blood.V89.12.4608. PMID 9192786. 
• "Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity.". Blood 97 (1): 312–20. 2001. doi:10.1182/blood.V97.1.312. PMID 11133776. http://www.bloodjournal.org/cgi/content/full/97/1/312. 
• "Characterization of the laminin binding domains of the Lutheran blood group glycoprotein.". J. Biol. Chem. 276 (26): 23757–62. 2001. doi:10.1074/jbc.M102978200. PMID 11319237. 
• "Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo.". J. Biol. Chem. 277 (47): 44864–9. 2003. doi:10.1074/jbc.M208731200. PMID 12244066. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function.". J. Biol. Chem. 278 (9): 7607–16. 2003. doi:10.1074/jbc.M210455200. PMID 12493773. 
• "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.". Nat. Biotechnol. 21 (6): 660–6. 2003. doi:10.1038/nbt827. PMID 12754519. 
• "Molecular bases of the antigens of the Lutheran blood group system.". Transfusion 43 (12): 1729–37. 2004. doi:10.1111/j.0041-1132.2003.00600.x. PMID 14641871. 
• "B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease.". Am. J. Hematol. 75 (2): 63–72. 2004. doi:10.1002/ajh.10442. PMID 14755370. 
• "Direct interaction between the Lu/B-CAM adhesion glycoproteins and erythroid spectrin.". Br. J. Haematol. 126 (2): 255–64. 2004. doi:10.1111/j.1365-2141.2004.05010.x. PMID 15238148. 
• "Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer.". Arch. Dermatol. Res. 296 (2): 59–66. 2005. doi:10.1007/s00403-004-0481-4. PMID 15278364. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.". Science 308 (5725): 1149–54. 2005. doi:10.1126/science.1108625. PMID 15790807. Bibcode: 2005Sci...308.1149C. 
• "Basal cell adhesion molecule promotes metastasis-associated processes in ovarian cancer.". Clin Transl Med 13 (1): e1176. 2023. doi:10.1002/ctm2.1176. PMID 36647260. 
• "Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells.". Am. J. Physiol., Cell Physiol. 290 (3): C764–75. 2006. doi:10.1152/ajpcell.00285.2005. PMID 16236823. 

External links

• BCAM+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human BCAM genome location and BCAM gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.