Chemistry:Ethylmorphine
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Short description: Opioid analgesic and antitussive drug
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| Trade names | Cosylan, Diolan, Dionina, Diosan, Solvipect, Trachyl |
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| Formula | C19H23NO3 |
| Molar mass | 313.397 g·mol−1 |
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Ethylmorphine (also known as codethyline, dionine, and ethyl morphine) is an opioid analgesic and antitussive.[1][2][3][4][5][6]
Side effects
Adverse effects are similar to other opioids and include drowsiness, constipation, vertigo, nausea, vomiting, and respiratory depression. Contraindications include asthma, respiratory insufficiency, and age under 8. Ethylmorphine may affect the user's ability to drive and operate heavy machinery, and may cause chemical dependence or addiction at high doses.[7]
Society and culture
Ethylmorphine was first marketed in France in 1953 by Houde, and in Norway and Spain in 1960. It is not available in the United States, where it is a Schedule II controlled substance.[7][8]
See also
References
- ↑ "Effects of ethanol on ethylmorphine metabolism in isolated rat hepatocytes: characterization by means of a multicompartmental model". Pharmacology & Toxicology 80 (4): 171–81. April 1997. doi:10.1111/j.1600-0773.1997.tb00392.x. PMID 9140136.
- ↑ "Fatal poisonings where ethylmorphine from antitussive medications contributed to death". International Journal of Legal Medicine 112 (5): 299–302. August 1999. doi:10.1007/s004140050253. PMID 10460420.
- ↑ "Morphine formation from ethylmorphine: implications for drugs-of-abuse testing in urine". Journal of Analytical Toxicology 22 (2): 142–7. March–April 1998. doi:10.1093/jat/22.2.142. PMID 9547411.
- ↑ "Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes". Toxicology Letters 94 (2): 115–25. January 1998. doi:10.1016/S0378-4274(97)00108-2. PMID 9574808.
- ↑ "Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose". British Journal of Clinical Pharmacology 39 (6): 611–20. June 1995. doi:10.1111/j.1365-2125.1995.tb05720.x. PMID 7654478.
- ↑ "Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism". British Journal of Clinical Pharmacology 39 (1): 77–80. January 1995. doi:10.1111/j.1365-2125.1995.tb04413.x. PMID 7756104.
- ↑ 7.0 7.1 Drugs Available Abroad, 1st Edition. Derwent Publications Ltd.. 1991. p. 79. ISBN 0-8103-7177-4.
- ↑ PubChem. "Ethylmorphine" (in en). https://pubchem.ncbi.nlm.nih.gov/compound/5359271.
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