Biology:Integrin alpha 5
From HandWiki
 Generic protein structure example |
Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.[1]
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[2]
Interactions
ITGA5 has been shown to interact with GIPC1.[3]
See also
References
- ↑ "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest 81 (6): 1993–8. Aug 1988. doi:10.1172/JCI113548. PMID 2454952.
- ↑ "Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3678.
- ↑ Tani, T T; Mercurio A M (Sep 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol. Chem. (United States) 276 (39): 36535–42. doi:10.1074/jbc.M105785200. ISSN 0021-9258. PMID 11479315.
Further reading
- Ruoslahti E (1996). "Integrin signaling and matrix assembly.". Tumour Biol. 17 (2): 117–24. doi:10.1159/000217975. PMID 8658014.
- "Expression and function of integrins on hematopoietic progenitor cells.". Acta Haematol. 97 (1–2): 13–21. 1997. doi:10.1159/000203655. PMID 8980606.
- "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell Biol. 8 (10): 390–6. 1999. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327.
- Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". BioEssays 23 (7): 628–39. doi:10.1002/bies.1088. PMID 11462216.
External links
- CD49e+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
- ITGA5 Info with links in the Cell Migration Gateway
- Overview of all the structural information available in the PDB for UniProt: P08648 (Human Integrin alpha-5) at the PDBe-KB.
 |  |
