Biology:Integrin alpha 6
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Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.
Function
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.[1] Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas.[2]
Interactions
ITGA6 has been shown to interact with TSPAN4[3] and GIPC1.[4]
See also
References
- ↑ "Entrez Gene: ITGA6 integrin, alpha 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3655.
- ↑ "Hemidesmosome integrity protects the colon against colitis and colorectal cancer". Gut 66 (10): 1748–1760. October 2017. doi:10.1136/gutjnl-2015-310847. PMID 27371534.
- ↑ "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". The Journal of Biological Chemistry 272 (46): 29181–9. November 1997. doi:10.1074/jbc.272.46.29181. PMID 9360996.
- ↑ "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". The Journal of Biological Chemistry 276 (39): 36535–42. September 2001. doi:10.1074/jbc.M105785200. PMID 11479315.
Further reading
- "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression". Cancer and Metastasis Reviews 24 (3): 413–23. September 2005. doi:10.1007/s10555-005-5133-4. PMID 16258729.
External links
- CD49f+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
- ITGA6 Info with links in the Cell Migration Gateway
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