Biology:Integrin alpha V
 Generic protein structure example |
Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.[1]
Function
ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.[2]
Alpha V class integrins
In mammals the integrins that include alpha-V are :
| Name | Synonyms | Distribution | Ligands |
| αVβ1 | neurological tumors | vitronectin; fibrinogen | |
| αVβ3 | vitronectin receptor[3] | activated endothelial cells, melanoma, glioblastoma | vitronectin,[3] fibronectin, fibrinogen, osteopontin, Cyr61 |
| αVβ5 | widespread, esp. fibroblasts, epithelial cells | vitronectin and adenovirus | |
| αVβ6 | proliferating epithelia, esp. lung and mammary gland | fibronectin; TGFβ1+3 | |
| αVβ8 | neural tissue; peripheral nerve | fibronectin; TGFβ1+3 |
Clinical significance
Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer,[4] and prostate cancer.[5]
As a drug target
The mAbs intetumumab, and abituzumab target this protein which is found on some tumour cells.[6]
See also
References
- ↑ "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". The Journal of Clinical Investigation 81 (6): 1993–8. June 1988. doi:10.1172/JCI113548. PMID 2454952.
- ↑ "Entrez Gene: ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3685.
- ↑ 3.0 3.1 "The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23". The Journal of Cell Biology 144 (4): 767–75. February 1999. doi:10.1083/jcb.144.4.767. PMID 10037797.
- ↑ "Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer". Anticancer Res 34 (10): 5599–607. 2014. PMID 25275062.
- ↑ "The role of alpha(v)beta(3) in prostate cancer progression". Neoplasia 4 (3): 191–4. 2002. doi:10.1038/sj.neo.7900224. PMID 11988838.
- ↑ "Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients with KRAS wild-type metastatic colorectal cancer: the randomised phase I/II POSEIDON trial". Annals of Oncology 26 (1): 132–40. January 2015. doi:10.1093/annonc/mdu474. PMID 25319061.
Further reading
- "The alpha v beta 3 integrin "vitronectin receptor"". The International Journal of Biochemistry & Cell Biology 29 (5): 721–5. May 1997. doi:10.1016/S1357-2725(96)00155-0. PMID 9251239.
- "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends in Cell Biology 8 (10): 390–6. October 1998. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327.
- "The role of alpha(v)beta3 integrins in vascular healing". Thrombosis and Haemostasis 87 (2): 187–93. February 2002. doi:10.1055/s-0037-1612971. PMID 11858476.
- "The role of alpha(v)beta(3) in prostate cancer progression". Neoplasia 4 (3): 191–4. 2002. doi:10.1038/sj.neo.7900224. PMID 11988838.
- "Non peptidic alphavbeta3 antagonists: recent developments". Current Medicinal Chemistry 12 (1): 51–70. 2005. doi:10.2174/0929867053363522. PMID 15638730.
- University of Edinburgh (2013). "Hope for transplant patients as study finds key to organ scarring". ScienceDaily. https://www.sciencedaily.com/releases/2013/11/131110184408.htm. Retrieved December 2, 2014.
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External links
- CD51+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
- ITGAV Info with links in the Cell Migration Gateway
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