Biology:Poliovirus receptor-related 3
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Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions.[1]
Function
Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells.[supplied by OMIM][1]
Interactions
PVRL3 has been shown to interact with:
See also
References
- ↑ 1.0 1.1 "Entrez Gene: PVRL3 poliovirus receptor-related 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25945.
- ↑ "Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell–cell adhesion activities". J. Biol. Chem. 275 (14): 10291–9. April 2000. doi:10.1074/jbc.275.14.10291. PMID 10744716.
- ↑ "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin". Gene 255 (2): 347–55. September 2000. doi:10.1016/s0378-1119(00)00316-4. PMID 11024295.
- ↑ "Direct binding of cell polarity protein PAR-3 to cell–cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. February 2003. doi:10.1074/jbc.C200707200. PMID 12515806.
- ↑ "Involvement of nectin in inactivation of integrin alpha(v)beta(3) after the establishment of cell–cell adhesion". J. Biol. Chem. 283 (1): 496–505. 2008. doi:10.1074/jbc.M704195200. PMID 17965016.
Further reading
- "Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell–cell adhesion activities". J. Biol. Chem. 275 (14): 10291–9. 2000. doi:10.1074/jbc.275.14.10291. PMID 10744716.
- "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin". Gene 255 (2): 347–55. 2000. doi:10.1016/S0378-1119(00)00316-4. PMID 11024295.
- "Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain". J. Biol. Chem. 277 (30): 27006–13. 2002. doi:10.1074/jbc.M203228200. PMID 12011057.
- "Direct binding of cell polarity protein PAR-3 to cell–cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. 2003. doi:10.1074/jbc.C200707200. PMID 12515806.
- "Recruitment of nectin-3 to cell–cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains". J. Biol. Chem. 278 (33): 31251–60. 2003. doi:10.1074/jbc.M304166200. PMID 12759359.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Inhibition of cell movement and proliferation by cell–cell contact-induced interaction of Necl-5 with nectin-3". J. Cell Biol. 171 (1): 165–73. 2005. doi:10.1083/jcb.200501090. PMID 16216929.
External links
- PVRL3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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