Chemistry:D-161

From HandWiki

D-161[1] is a chemical known in research circles as a triple reuptake inhibitor. Although this compound has lent support to the inclusion of dopamine in the monoamine hypothesis of depression, D-161 has not been tested in clinical trials.

A more recent study was reported.[2]

A couple of patents are also disclosed.[3][4]

Synthesis

The synthesis of this agent has been reported.[5][6]

References

  1. ↑ "D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action". European Journal of Pharmacology 589 (1–3): 73–9. July 2008. doi:10.1016/j.ejphar.2008.05.008. PMID 18561912. 
  2. ↑ "Flexible and biomimetic analogs of triple uptake inhibitor 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: Synthesis, biological characterization, and development of a pharmacophore model". Bioorganic & Medicinal Chemistry 22 (1): 311–324. January 2014. doi:10.1016/j.bmc.2013.11.017. ISSN 09680896. https://linkinghub.elsevier.com/retrieve/pii/S0968089613009486. Retrieved 6 December 2025. 
  3. ↑ Aloke K. Dutta, WO2005105075 (Wayne State University).
  4. ↑ Aloke K. Dutta, US8017791 (2011 to Wayne State University).
  5. ↑ "Further Structural Exploration of Trisubstituted Asymmetric Pyran Derivatives (2 S ,4 R ,5 R )-2-Benzhydryl-5-benzylamino-tetrahydropyran-4-ol and Their Corresponding Disubstituted (3 S ,6 S ) Pyran Derivatives: A Proposed Pharmacophore Model for High-Affinity Interaction with the Dopamine, Serotonin, and Norepinephrine Transporters". Journal of Medicinal Chemistry 49 (14): 4239–4247. 1 July 2006. doi:10.1021/jm0601699. https://pubs.acs.org/doi/10.1021/jm0601699. 
  6. ↑ "Further Structure−Activity Relationship Studies on 4-((((3 S ,6 S )-6-Benzhydryltetrahydro-2 H -pyran-3-yl)amino)methyl)phenol: Identification of Compounds with Triple Uptake Inhibitory Activity as Potential Antidepressant Agents". Journal of Medicinal Chemistry 54 (8): 2924–2932. 28 April 2011. doi:10.1021/jm200020a. PMC 3085959. https://pubs.acs.org/doi/10.1021/jm200020a. 




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