Chemistry:Talsupram
From HandWiki
Short description: Chemical compound
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| Routes of administration | Oral |
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| Formula | C20H25NS |
| Molar mass | 311.49 g·mol−1 |
Talsupram (Lu 5-005 or Lu 5-003[1]) is a selective norepinephrine reuptake inhibitor (NRI) which was investigated as an antidepressant in the 1960s and 1970s but was never marketed.[2][3][4] Along with talopram, it is structurally related to the selective serotonin reuptake inhibitor (SSRI) citalopram.[5]
See also
References
- ↑ Carlsson, A.; Fuxe, K.; Hamberger, B.; Malmfors, T. (May 1969). "Effect of a new series of bicyclic compounds with potential thymoleptic properties on the reserpine-resistant uptake mechanism of central and peripheral monoamine neurones in vivo and in vitro". British Journal of Pharmacology 36 (1): 18–28. doi:10.1111/j.1476-5381.1969.tb08299.x. ISSN 0007-1188. OCLC 6895508396. PMID 5768100.
- ↑ Pawłowski, L.; Mazela, H. (June 1986). "Effects of antidepressant drugs, selective noradrenaline-or 5-hydroxytryptamine uptake inhibitors, on apomorphine-induced hypothermia in mice". Psychopharmacology 88 (2): 240–246. doi:10.1007/BF00652248. ISSN 0033-3158. OCLC 5653283278. PMID 3006113.
- ↑ "Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter". Nuclear Medicine and Biology 31 (6): 705–18. August 2004. doi:10.1016/j.nucmedbio.2003.05.001. PMID 15246361.
- ↑ "Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test". Psychoneuroendocrinology 28 (3): 332–47. April 2003. doi:10.1016/S0306-4530(02)00026-4. PMID 12573300.
- ↑ "The SSRI Issues" (DOC). http://www.healyprozac.com/Book/Introduction.doc.
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