Chemistry:O-2172
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Short description: Chemical compound
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| Formula | C14H16Cl2O2 |
| Molar mass | 287.18 g·mol−1 |
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O-2172 is a drug developed by Organix Inc, which acts as a stimulant and potent dopamine reuptake inhibitor. It is an analogue of methylphenidate where the phenyl ring has had a 3,4-dichloro substitution added, and the piperidine ring has been replaced by cyclopentane. It is around 1/3 the potency of methylphenidate, demonstrating that even with the important binding group of the nitrogen lone pair removed entirely, selective DAT binding and reuptake inhibition is still possible.[1][2]
See also
References
- ↑ "Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate". Journal of Medicinal Chemistry 46 (8): 1538–45. April 2003. doi:10.1021/jm0205292. PMID 12672255.
- ↑ "Dopamine transporter ligands: recent developments and therapeutic potential". Current Topics in Medicinal Chemistry 6 (17): 1825–43. 2006. doi:10.2174/156802606778249775. PMID 17017960.
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