Chemistry:RTI-150
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| Formula | C20H27NO2 |
| Molar mass | 313.441 g·mol−1 |
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RTI(-4229)-150, ((−)-2β-Carbocyclobutoxy-3β-(4-methylphenyl)tropane) is a phenyltropane derivative which acts as a potent dopamine reuptake inhibitor and stimulant drug. It is around 5x more potent than cocaine, but is more selective for the dopamine transporter relative to the other monoamine transporters. RTI-150 has a fast onset of effects and short duration of action, and its abuse potential in animal studies is similar to that of cocaine itself; its main application in scientific research has been in studies investigating the influence of pharmacokinetics on the abuse potential of stimulant drugs, with the rapid entry of RTI-150 into the brain thought to be a key factor in producing its high propensity for development of dependence in animals.[1][2][3] RTI-150 is not explicitly illegal anywhere in the world, but its similar structure and pharmacological activity to cocaine makes it possible that it would be considered a controlled substance analogue in countries such as the US, Canada, Australia and New Zealand which have controlled substance analogue legislation.
See also
References
- ↑ "Locomotor stimulant effects of novel phenyltropanes in the mouse". Drug and Alcohol Dependence 65 (1): 25–36. December 2001. doi:10.1016/s0376-8716(01)00144-2. PMID 11714587.
- ↑ "Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys". Pharmacology, Biochemistry, and Behavior 86 (1): 45–54. January 2007. doi:10.1016/j.pbb.2006.12.006. PMID 17258302.
- ↑ "Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys". Pharmacology, Biochemistry, and Behavior 90 (3): 453–62. September 2008. doi:10.1016/j.pbb.2008.03.032. PMID 18468667.
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