Chemistry:Difemetorex
From HandWiki
Short description: Piperidine class stimulant
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| Routes of administration | Oral |
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| Formula | C20H25NO |
| Molar mass | 295.426 g·mol−1 |
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Difemetorex (INN; sold as Cleofil), also known as diphemethoxidine, is a stimulant drug of the piperidine class which was used as an appetite suppressant, but produced intolerable side effects such as insomnia which limited its clinical use.[1][2][3][4][5] It was introduced in France by Ciba-Geigy in 1966 but is now no longer marketed.[6]
Synthesis
Patent:[7]
Alkylation of desoxypipradrol with ethyleneoxide gives difemetorex.
See also
References
- ↑ "Dependence liability of "non-narcotic" drugs". Bulletin of the World Health Organization 43 Suppl (Suppl): 1–111. 1970. PMID 4949109.
- ↑ "[Circulatory effects of the anorectic Diphemethoxidine compared with the effects of Amphetamine and Aminorex]". Archives Internationales de Pharmacodynamie et de Therapie 191 (2): 376–99. June 1971. PMID 5089225.
- ↑ "[Alteration of the acid-base equilibrium by the anorectic diphemethoxidine in comparison with the effect of amphetamine and aminorex]". Archives Internationales de Pharmacodynamie et de Therapie 199 (1): 122–38. September 1972. PMID 5072180.
- ↑ Concise dictionary of pharmacological agents: properties and synonyms. Kluwer Academic. 1999. ISBN 0-7514-0499-3. https://books.google.com/books?id=mqaOMOtk61IC&pg=PA98.
- ↑ "The use of common stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances". https://www.who.int/medicinedocs/collect/edmweb/pdf/s4895e/s4895e.pdf.[|permanent dead link|dead link}}]
- ↑ Médicaments pour tous en l'an 2000?: les multinationales pharmaceutiques suisses face au tiers monde : l'exemple du Mexique. France: Editions d'En bas. 1983. pp. 207. ISBN 2-8290-0039-0. https://books.google.com/books?id=ZgLwphUSEN0C&pg=PA92.
- ↑ "New hydroxyalkyl-piperidines" GB patent 861815, issued 1961, assigned to CIBA Ltd
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