Chemistry:Altropane
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Short description: Stimulant drug
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| Formula | C18H21FINO2 |
| Molar mass | 429.274 g·mol−1 |
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Altropane (O-587, IACFT, 2β-carbomethoxy-3β-(4-fluorophenyl)-N-((E)-3-iodo-prop-2-enyl)tropane) is a phenyltropane derivative which acts as a potent dopamine reuptake inhibitor and long-acting stimulant drug. It has mainly been used as the 125I radiolabelled form for mapping the distribution of dopamine transporters in the brain,[1] and consequently this has led to its development as a potential diagnostic tool for early detection of Parkinson's disease.[2] It is also being investigated for potential use in the diagnosis and treatment of attention deficit hyperactivity disorder (ADHD).[3][4]
References
- ↑ "Preparation and biological evaluation of iodine-125-IACFT: a selective SPECT agent for imaging dopamine transporter sites". Journal of Nuclear Medicine 37 (7): 1197–202. July 1996. PMID 8965198.
- ↑ "Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters". Synapse 29 (2): 128–41. June 1998. doi:10.1002/(SICI)1098-2396(199806)29:2<128::AID-SYN4>3.0.CO;2-9. PMID 9593103.
- ↑ "Altropane (Boston Life Science)". Current Opinion in Investigational Drugs 3 (11): 1647–51. November 2002. PMID 12476968.
- ↑ "Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropane". Biological Psychiatry 62 (9): 1059–61. November 2007. doi:10.1016/j.biopsych.2006.12.008. PMID 17511972.
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