Chemistry:Daledalin
From HandWiki
Short description: Chemical compound
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| Formula | C19H24N2 |
| Molar mass | 280.415 g·mol−1 |
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Daledalin (UK-3557-15) is an antidepressant which was synthesized and trialed for depression in the early 1970s, but was never marketed.[1][2][3] It is a selective norepinephrine reuptake inhibitor, with no significant effects on the reuptake of serotonin and dopamine, and no antihistamine or anticholinergic properties.[2][4]
Synthesis
Daledalin synthesis:[2]
See also
References
- ↑ Triggle, David J. (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 978-0-412-46630-4. https://books.google.com/books?id=DeX7jgInYFMC&q=daledalin&pg=PA565.
- ↑ 2.0 2.1 2.2 "N-Phenyl-2-indolinones and N-phenylindolines. A new class of antidepressant agents". Journal of Medicinal Chemistry 15 (7): 762–70. July 1972. doi:10.1021/jm00277a017. PMID 5043876.
- ↑ "Daledalin tosylate: a controlled trial in depressive illness". Current Medical Research and Opinion 2 (6): 305–12. 1974. doi:10.1185/03007997409114763. PMID 4614944.
- ↑ "Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain". Journal of Pharmacology and Experimental Therapeutics 199 (3): 649–661. December 1976. PMID 994022. http://jpet.aspetjournals.org/content/199/3/649.abstract.
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