Chemistry:EXP-561
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Short description: Chemical compound
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| Routes of administration | Oral |
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| Formula | C14H19N |
| Molar mass | 201.313 g·mol−1 |
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EXP-561[1] is an investigational drug that acts as an inhibitor of the reuptake of serotonin, dopamine, and norepinephrine.[2][3][4][5] It was developed in the 1960s by Du Pont[6] and was suggested as a potential antidepressant but failed in trials[7] and was never marketed.[5][8][9][10]
References
- ↑ US 3362878 - Pharmaceutical compositions and methods utilizing substituted bicyclo[2.2.2]-octanes
- ↑ "Inhibition of amine uptake by 4-phenyl-bicyclo(2,2,2)octan-1-amine hydrochloride monohydrate (EXP 561) in rats". Biochemical Pharmacology 25 (21): 2409–10. November 1976. doi:10.1016/0006-2952(76)90039-3. PMID 999731.
- ↑ Koe BK (December 1976). "Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain". The Journal of Pharmacology and Experimental Therapeutics 199 (3): 649–61. PMID 994022. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=994022.
- ↑ "Blockade of monoamine uptake by 1-amino-4-phenylbicyclo(2,2,2)octane (EXP 561) in rat brain and heart". Neuropharmacology 16 (1): 11–5. January 1977. doi:10.1016/0028-3908(77)90040-5. PMID 834358.
- ↑ 5.0 5.1 "Pharmacological properties of EXP 561, a potential antidepressant drug". Journal of Neural Transmission 70 (1–2): 81–97. 1987. doi:10.1007/BF01252511. PMID 2822850.
- ↑ US Patent 3308160 - PHENYLBICYCLO[Z.Z.Z]OCTANE-L-AMINES AND SALTS THEREOF
- ↑ INTERNATIONAL REVIEW NEUROBIOLOGY, Volume 12 Page 160
- ↑ "A clinical-pharmacological study with EXP 561". Current Therapeutic Research, Clinical and Experimental 9 (6): 306–8. June 1967. PMID 4963065.
- ↑ "Non-correlation of preclinical-clinical evaluation of a prosposed anti-depressant 4-phenyl-bicyclo(2,2,2)octan-1-amine hydrochloride monohydrate (EXP 561)". Arzneimittel-Forschung 18 (2): 243–5. February 1968. PMID 5695389.
- ↑ "Inhibition of 3H-dopamine accumulation in reserpinized and normal rat striatum". Acta Pharmacologica et Toxicologica 44 (5): 329–35. May 1979. doi:10.1111/j.1600-0773.1979.tb02339.x. PMID 474143.
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