Chemistry:JZ-IV-10
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Short description: Chemical compound
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| Formula | C18H27ClN2OS |
| Molar mass | 354.94 g·mol−1 |
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JZ-IV-10 is a piperidine derivative related to cocaine which acts as a highly potent serotonin–norepinephrine–dopamine reuptake inhibitor (also called SNDRI, or triple reuptake inhibitor).[1] The eugeroic modafinil was used as a lead to fuel this compound's discovery.[2][3]
See also
- 1-Methyl-3-propyl-4-(p-chlorophenyl)piperidine
- N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate
- Nocaine
References
- ↑ Kozikowski, Alan P. & Jia Zhou, "Dopamine-, norepinephrine- and serotonin- transporter- selective heterocyclic compounds and their therapeutic applications", WO patent 2005041875, published 2005-05-12
- ↑ "Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization". Journal of Medicinal Chemistry 47 (24): 5821–4. November 2004. doi:10.1021/jm040117o. PMID 15537337.
- ↑ "Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhibitors". Journal of Medicinal Chemistry 48 (25): 7970–9. December 2005. doi:10.1021/jm050694s. PMID 16335921.
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