Chemistry:O-823
From HandWiki
Short description: Chemical compound
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| Formula | C23H27NO2 |
| Molar mass | 349.474 g·mol−1 |
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O-823 is a drug which is a cannabinoid derivative that is used in scientific research. It is described as a mixed agonist/antagonist at the cannabinoid receptor CB1, meaning that it acts as an antagonist when co-administered alongside a more potent CB1 agonist, but exhibits weak partial agonist effects when administered by itself.[1][2][3]
References
- ↑ "Agonist-antagonist characterization of 6'-cyanohex-2'-yne-delta 8-tetrahydrocannabinol in two isolated tissue preparations". European Journal of Pharmacology 315 (2): 195–201. November 1996. doi:10.1016/s0014-2999(96)00631-0. PMID 8960884.
- ↑ "An investigation into the structural determinants of cannabinoid receptor ligand efficacy". British Journal of Pharmacology 126 (7): 1575–84. April 1999. doi:10.1038/sj.bjp.0702469. PMID 10323589.
- ↑ "Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum". British Journal of Pharmacology 128 (3): 684–8. October 1999. doi:10.1038/sj.bjp.0702806. PMID 10516649.
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