|Chemical and physical data|
|Molar mass||401.93 g·mol−1|
|3D model (JSmol)|
JWH-369 ((5-(2-chlorophenyl)-1-pentyl-1H-pyrrol-3-yl)(naphthalen-1-yl)methanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as a potent agonist of the CB1 (Ki = 7.9 ± 0.4nM) and CB2 (Ki = 5.2 ± 0.3nM) receptors, with a slight selectivity for the latter. JWH-369 was first synthesized in 2006 by John W. Huffman and colleagues to examine the nature of ligand binding to the CB1 receptor.
In Canada, JWH-369 and other naphthoylpyrrole-based cannabinoids are Schedule II controlled substances under the Controlled Drugs and Substances Act.
In the United Kingdom, JWH-369 and other naphthoylpyrrole-based cannabinoids are considered Class B drugs under the Misuse of Drugs Act 1971.
- "1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors". Bioorganic & Medicinal Chemistry Letters 16 (20): 5432–5. October 2006. doi:10.1016/j.bmcl.2006.07.051. PMID 16889960.
- : Schedules of controlled substances
- "The 2020 Florida Statutes". http://www.leg.state.fl.us/Statutes/index.cfm?App_mode=Display_Statute&URL=0800-0899/0893/Sections/0893.03.html.
- "Arizona Revised Statutes Title 13. Criminal Code § 13-3401". https://www.azleg.gov/ars/13/03401.htm.
- "California Code, Health and Safety Code - HSC § 11357.5". https://codes.findlaw.com/ca/health-and-safety-code/hsc-sect-11357-5.html.
Original source: https://en.wikipedia.org/wiki/JWH-369. Read more