Chemistry:O-1871
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Short description: Chemical compound
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| Formula | C23H38O2 |
| Molar mass | 346.555 g·mol−1 |
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O-1871 is a potent cannabinoid agonist which was invented by Billy R Martin and Raj K Razdan at Organix Inc in 2002. It has a CB1 receptor affinity of 2.0 nM and a CB2 receptor affinity of 0.3 nM.[1] Structurally, O-1871 is a cyclohexylphenol derivative related to CP 47,497,[2] and so is illegal in some jurisdictions where CP 47,497 and its derivatives are banned. However the 3,3-dimethylcyclohexyl substituent of O-1871 can be replaced by various other groups, producing other potent compounds such as the cycloheptyl derivative O-1656 and the 2-adamantyl derivative O-1660, as well as the corresponding 3,5-dichlorophenyl derivative,[3] which are not cyclohexylphenol derivatives.
O-1656, CAS# 468083-75-2 [1]
O-1660, [2]
See also
References
- ↑ Martin BR, Razdan RK, "Cannabinoids", WO patent application 03091189, published 6 November 2003, assigned to University of Virginia
- ↑ "Emerging drugs of abuse: current perspectives on synthetic cannabinoids". Substance Abuse and Rehabilitation 6: 113–29. 2015. doi:10.2147/SAR.S73586. PMID 26543389.
- ↑ Lai XZ, Lu D, Makriyannis A, "Novel biphenyl and biphenyl-like cannabinoids", US patent application 2004087590, published 6 May 2004, assigned to University of Connecticut
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