Chemistry:AMG-41
From HandWiki
Short description: Chemical compound
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| Formula | C25H36O2 |
| Molar mass | 368.561 g·mol−1 |
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AMG-41 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8-THC substituted with a cyclopropyl group on the C1'-position of the C3-alkyl side chain. AMG-41 is a potent agonist at both CB1 and CB2, with a Ki of 0.44 nM at CB1 vs 0.86 nM at CB2.[1][2][3]
See also
References
- ↑ "Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols". Bioorganic & Medicinal Chemistry Letters 12 (24): 3583–6. December 2002. doi:10.1016/s0960-894x(02)00785-0. PMID 12443781.
- ↑ "Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'". Journal of Medicinal Chemistry 46 (15): 3221–9. July 2003. doi:10.1021/jm020558c. PMID 12852753.
- ↑ "C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols". Journal of Medicinal Chemistry 50 (17): 4048–60. August 2007. doi:10.1021/jm070121a. PMID 17672444.
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